CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013211
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-glyceraldehyde 3-phosphate reductase 
Protein Synonyms/Alias
 GAP reductase 
Gene Name
 gpr 
Gene Synonyms/Alias
 mgrA; yghZ; b3001; JW2970 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
177YSPERTQKMVELLREacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non- enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MVWLANPERY GQMQYRYCGK SGLRLPALSL GLWHNFGHVN ALESQRAILR KAFDLGITHF 60
DLANNYGPPP GSAEENFGRL LREDFAAYRD ELIISTKAGY DMWPGPYGSG GSRKYLLASL 120
DQSLKRMGLE YVDIFYSHRV DENTPMEETA SALAHAVQSG KALYVGISSY SPERTQKMVE 180
LLREWKIPLL IHQPSYNLLN RWVDKSGLLD TLQNNGVGCI AFTPLAQGLL TGKYLNGIPQ 240
DSRMHREGNK VRGLTPKMLT EANLNSLRLL NEMAQQRGQS MAQMALSWLL KDDRVTSVLI 300
GASRAEQLEE NVQALNNLTF STKELAQIDQ HIADGELNLW QASSDK 346 
Gene Ontology
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IDA:EcoCyc.
 GO:0009438; P:methylglyoxal metabolic process; IDA:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
  
PRINTS