| Tag | Content |
|---|
| CPLM ID | CPLM-017221 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | G-protein coupled receptor 56 |
Protein Synonyms/Alias | Serpentine receptor cyt28; GPR56 N-terminal fragment; GPR56 NT; GPR56(N); GPR56 extracellular subunit; GPR56 subunit alpha; GPR56 C-terminal fragment; GPR56 CT; GPR56(C); GPR56 seven-transmembrane subunit; GPR56 7TM; GPR56 subunit beta |
Gene Name | Gpr56 |
Gene Synonyms/Alias | Cyt28 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 674 | KNNSDSAKLPISSGS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/Col3a1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the Col3a1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to Gna13 and possibly Gna12. |
Sequence Annotation | DOMAIN 343 394 GPS.
CARBOHYD 39 39 N-linked (GlcNAc...).
CARBOHYD 148 148 N-linked (GlcNAc...).
CARBOHYD 171 171 N-linked (GlcNAc...).
CARBOHYD 234 234 N-linked (GlcNAc...).
CARBOHYD 303 303 N-linked (GlcNAc...).
CARBOHYD 324 324 N-linked (GlcNAc...).
CARBOHYD 341 341 N-linked (GlcNAc...). |
Keyword | Cell adhesion; Cell membrane; Complete proteome; Developmental protein; Differentiation; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Reference proteome; Secreted; Signal; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 687 AA |
Protein Sequence | MAVQVLRQMV YFLLSLFSLV QGAHSGSPRE DFRFCGQRNQ TQQSTLHYDQ SSEPHIFVWN 60
TEETLTIRAP FLAAPDIPRF FPEPRGLYHF CLYWSRHTGR LHLRYGKHDY LLSSQASRLL 120
CFQKQEQSLK QGAPLIATSV SSWQIPQNTS LPGAPSFIFS FHNAPHKVSH NASVDMCDLK 180
KELQQLSRYL QHPQKAAKRP TAAFISQQLQ SLESKLTSVS FLGDTLSFEE DRVNATVWKL 240
PPTAGLEDLH IHSQKEEEQS EVQAYSLLLP RAVFQQTRGR RRDDAKRLLV VDFSSQALFQ 300
DKNSSQVLGE KVLGIVVQNT KVTNLSDPVV LTFQHQPQPK NVTLQCVFWV EDPASSSTGS 360
WSSAGCETVS RDTQTSCLCN HLTYFAVLMV SSTEVEATHK HYLTLLSYVG CVISALACVF 420
TIAAYLCSRR KSRDYTIKVH MNLLSAVFLL DVSFLLSEPV ALTGSEAACR TSAMFLHFSL 480
LACLSWMGLE GYNLYRLVVE VFGTYVPGYL LKLSIVGWGF PVFLVTLVAL VDVNNYGPII 540
LAVRRTPERV TYPSMCWIRD SLVSYVTNLG LFSLVFLFNL AMLATMVVQI LRLRPHSQNW 600
PHVLTLLGLS LVLGLPWALV FFSFASGTFQ LVILYLFSII TSFQGFLIFL WYWSMRFQAQ 660
GGPSPLKNNS DSAKLPISSG STSSSRI 687 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW. GO:0007420; P:brain development; IEA:Compara. GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |