UniProt Accession

 H0YKZ9_HUMAN; H0YKZ9 

Genbank Protein ID

 AC016207 

Genbank Nucleotide ID

  

Protein Name

 Gamma-secretase subunit APH-1B 

Protein Synonyms/Alias

  

Gene Name

 APH1B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	MFRFAYYKLLKKASE	ubiquitination	[1]
48	KKASEGLKSINPGET	ubiquitination	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0043085; P:positive regulation of catalytic activity; IEA:InterPro.
 GO:0016485; P:protein processing; IEA:InterPro. 

Interpro

 IPR009294; Aph-1. 

Pfam

 PF06105; Aph-1 

SMART

  

PROSITE

  

PRINTS