UniProt Accession

 LAYN_HUMAN; Q6UX15; A6NJB0; Q8TAY8; Q96NC5; Q96NF3 

Genbank Protein ID

 AY358554; AK055539; AK055654; AP002008; CH471065; BC025407 

Genbank Nucleotide ID

 AAQ88918.1; BAB70946.1; BAB70978.1; EAW67145.1; AAH25407.1 

Protein Name

 Layilin 

Protein Synonyms/Alias

  

Gene Name

 LAYN 

Gene Synonyms/Alias

 UNQ208/PRO234 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
311	AETRPDLKNISFRVC	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Receptor for hyaluronate. 

Sequence Annotation

 DOMAIN 45 185 C-type lectin.
 REPEAT 340 344 1-1.
 REPEAT 350 354 1-2.
 REPEAT 356 359 2-1.
 REPEAT 371 375 1-3.
 REPEAT 377 380 2-2.
 REGION 330 374 Interaction with NF2 (By similarity).
 REGION 337 382 Interaction with TLN1 (By similarity).
 REGION 340 375 3 X 5 AA repeats of E-S-G-X-V.
 REGION 356 380 2 X 4 AA repeats of N-X-I-Y.
 MOD_RES 286 286 Phosphoserine (By similarity).
 MOD_RES 299 299 Phosphoserine (By similarity).
 CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
 DISULFID 71 184 By similarity.
 DISULFID 150 176 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Lectin; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 382 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; ISS:HGNC.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0001726; C:ruffle; ISS:HGNC.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0005540; F:hyaluronic acid binding; IDA:HGNC. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold. 

Pfam

 PF00059; Lectin_C 

SMART

 SM00034; CLECT 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2 

PRINTS