UniProt Accession

 FABPL_RAT; P02692 

Genbank Protein ID

 V01235; M13501; M35991; S55929; BC086947; M17899; M10951 

Genbank Nucleotide ID

 CAA24545.1; AAA41140.1; AAA41135.1; AAB19788.1; AAH86947.1; AAA41134.1; AAA42119.1 

Protein Name

 Fatty acid-binding protein, liver 

Protein Synonyms/Alias

 Fatty acid-binding protein 1; Liver-type fatty acid-binding protein; L-FABP; Squalene- and sterol-carrier protein; SCP; Z-protein; p14 

Gene Name

 Fabp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MNFSGKYQVQSQE	acetylation	[1]
31	LPEDLIQKGKDIKGV	acetylation	[1]
36	IQKGKDIKGVSEIVH	acetylation	[1]
46	SEIVHEGKKVKLTIT	acetylation	[1]
49	VHEGKKVKLTITYGS	acetylation	[1]
84	EKVKAVVKMEGDNKM	acetylation	[1]
90	VKMEGDNKMVTTFKG	acetylation	[1]
96	NKMVTTFKGIKSVTE	acetylation	[1]
99	VTTFKGIKSVTEFNG	acetylation	[1]
121	TLGDIVYKRVSKRI*	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. 

Sequence Annotation

 REGION 54 56 Fatty acid 1 binding.
 BINDING 31 31 Fatty acid 1.
 BINDING 39 39 Fatty acid 2.
 BINDING 122 122 Fatty acid 2.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 105 105 Aspartyl isopeptide (Asn).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0045179; C:apical cortex; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005782; C:peroxisomal matrix; IDA:RGD.
 GO:0016209; F:antioxidant activity; IEA:Compara.
 GO:0032052; F:bile acid binding; IMP:RGD.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0008144; F:drug binding; IPI:RGD.
 GO:0005504; F:fatty acid binding; IDA:RGD.
 GO:0005324; F:long-chain fatty acid transporter activity; IMP:RGD.
 GO:0051978; F:lysophospholipid transporter activity; IC:RGD.
 GO:0005543; F:phospholipid binding; IMP:RGD.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0050892; P:intestinal absorption; IDA:RGD.
 GO:0007067; P:mitosis; TAS:RGD.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEP:RGD.
 GO:0032000; P:positive regulation of fatty acid beta-oxidation; IDA:RGD.
 GO:0051345; P:positive regulation of hydrolase activity; IDA:RGD. 

Interpro

 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR000463; Fatty_acid-bd.
 IPR000566; Lipocln_cytosolic_FA-bd_dom. 

Pfam

 PF00061; Lipocalin 

SMART

  

PROSITE

 PS00214; FABP 

PRINTS

 PR00178; FATTYACIDBP.