UniProt Accession

 K7EK97_HUMAN; K7EK97 

Genbank Protein ID

 AC092309; AC138128; AC138534; AC139353 

Genbank Nucleotide ID

  

Protein Name

 DNA excision repair protein ERCC-1 

Protein Synonyms/Alias

  

Gene Name

 ERCC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
37	EVPPGVAKPLFRSTQ	acetylation	[1]
37	EVPPGVAKPLFRSTQ	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 141 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003684; F:damaged DNA binding; IEA:InterPro.
 GO:0004519; F:endonuclease activity; IEA:InterPro.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0051276; P:chromosome organization; IEA:Compara.
 GO:0006302; P:double-strand break repair; IEA:Compara.
 GO:0048568; P:embryonic organ development; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0045190; P:isotype switching; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0010259; P:multicellular organismal aging; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0048477; P:oogenesis; IEA:Compara.
 GO:0035166; P:post-embryonic hemopoiesis; IEA:Compara.
 GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IEA:Compara.
 GO:0001302; P:replicative cell aging; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0009744; P:response to sucrose stimulus; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0006949; P:syncytium formation; IEA:Compara.
 GO:0009650; P:UV protection; IEA:Compara. 

Interpro

 IPR004579; DNA_repair_Rad10.
 IPR011335; Restrct_endonuc-II-like. 

Pfam

 PF03834; Rad10 

SMART

  

PROSITE

  

PRINTS