CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021986
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Semaphorin-4B 
Protein Synonyms/Alias
  
Gene Name
 SEMA4B 
Gene Synonyms/Alias
 KIAA1745; SEMAC; UNQ749/PRO1480 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
740YRHRNSMKVFLKQGEubiquitination[1, 2]
744NSMKVFLKQGECASVubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). 
Sequence Annotation
 DOMAIN 42 518 Sema.
 DOMAIN 520 574 PSI.
 DOMAIN 599 658 Ig-like C2-type.
 MOD_RES 813 813 Phosphoserine.
 MOD_RES 825 825 Phosphoserine.
 CARBOHYD 64 64 N-linked (GlcNAc...).
 CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
 CARBOHYD 160 160 N-linked (GlcNAc...) (Potential).
 CARBOHYD 405 405 N-linked (GlcNAc...).
 CARBOHYD 520 520 N-linked (GlcNAc...) (Potential).
 CARBOHYD 625 625 N-linked (GlcNAc...) (Potential).
 DISULFID 115 126 By similarity.
 DISULFID 144 153 By similarity.
 DISULFID 281 394 By similarity.
 DISULFID 305 354 By similarity.
 DISULFID 521 538 By similarity.
 DISULFID 606 651 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 832 AA 
Protein Sequence
MGLRSWLAAP WGALPPRPPL LLLLLLLLLL QPPPPTWALS PRISLPLGSE ERPFLRFEAE 60
HISNYTALLL SRDGRTLYVG AREALFALSS NLSFLPGGEY QELLWGADAE KKQQCSFKGK 120
DPQRDCQNYI KILLPLSGSH LFTCGTAAFS PMCTYINMEN FTLARDEKGN VLLEDGKGRC 180
PFDPNFKSTA LVVDGELYTG TVSSFQGNDP AISRSQSLRP TKTESSLNWL QDPAFVASAY 240
IPESLGSLQG DDDKIYFFFS ETGQEFEFFE NTIVSRIARI CKGDEGGERV LQQRWTSFLK 300
AQLLCSRPDD GFPFNVLQDV FTLSPSPQDW RDTLFYGVFT SQWHRGTTEG SAVCVFTMKD 360
VQRVFSGLYK EVNRETQQWY TVTHPVPTPR PGACITNSAR ERKINSSLQL PDRVLNFLKD 420
HFLMDGQVRS RMLLLQPQAR YQRVAVHRVP GLHHTYDVLF LGTGDGRLHK AVSVGPRVHI 480
IEELQIFSSG QPVQNLLLDT HRGLLYAASH SGVVQVPMAN CSLYRSCGDC LLARDPYCAW 540
SGSSCKHVSL YQPQLATRPW IQDIEGASAK DLCSASSVVS PSFVPTGEKP CEQVQFQPNT 600
VNTLACPLLS NLATRLWLRN GAPVNASASC HVLPTGDLLL VGTQQLGEFQ CWSLEEGFQQ 660
LVASYCPEVV EDGVADQTDE GGSVPVIIST SRVSAPAGGK ASWGADRSYW KEFLVMCTLF 720
VLAVLLPVLF LLYRHRNSMK VFLKQGECAS VHPKTCPVVL PPETRPLNGL GPPSTPLDHR 780
GYQSLSDSPP GSRVFTESEK RPLSIQDSFV EVSPVCPRPR VRLGSEIRDS VV 832 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW. 
Interpro
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002165; Plexin_repeat.
 IPR027231; Semaphorin.
 IPR001627; Semaphorin/CD100_Ag.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF01437; PSI
 PF01403; Sema 
SMART
 SM00423; PSI
 SM00630; Sema 
PROSITE
 PS51004; SEMA 
PRINTS