CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039601
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mannose-6-phosphate isomerase 
Protein Synonyms/Alias
  
Gene Name
 MPI 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
113EIVTFLKKVPEFQFLubiquitination[1]
168EQLNLLVKRISQQAAubiquitination[1]
270SYTPSSSKDRLFLPTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Isomerase; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 373 AA 
Protein Sequence
MGTHPRGDAK ILDNRISQKT LSQWIAENQD SLGSKVKDTF NGNLPFLFKV LSVETPLSIQ 60
AHPNKELAEK LHLQAPQHYP DANHKPEMAI ALTPFQGLCG FRPVEEIVTF LKKVPEFQFL 120
IGDEAATHLK QTMSHDSQAV ASSLQSCFSH LMKSEKKVVV EQLNLLVKRI SQQAAAGNNM 180
EDIFGELLLQ LHQQYPGDIG CFAIYFLNLL TLKPGEAMFL EANVPHAYLK GDCVECMACS 240
DNTVRAGLTP KFIDVPTLCE MLSYTPSSSK DRLFLPTRSQ EDPYLSIYDP PVPDFTIMKT 300
EVPGSVTEYK VLALDSASIL LMVQGTVIAS TPTTQTPIPL QRGGVLFIGA NESVSLKLTE 360
PKDLLIFRAC CLL 373 
Gene Ontology
 GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001250; Man6P_Isoase-1.
 IPR016305; Mannose-6-P_Isomerase.
 IPR018050; Pmannose_isomerase-type1_CS.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 
Pfam
 PF01238; PMI_typeI 
SMART
  
PROSITE
 PS00965; PMI_I_1
 PS00966; PMI_I_2 
PRINTS
 PR00714; MAN6PISMRASE.