UniProt Accession

 MSRB1_MOUSE; Q9JLC3; Q545U8 

Genbank Protein ID

 AF195142; AK002339; AK002652; AK003112; AK003624; BC090646 

Genbank Nucleotide ID

 AAF13697.1; BAC55245.1; BAE43148.1; BAC55248.1; BAC55249.1; AAH90646.1 

Protein Name

 Methionine-R-sulfoxide reductase B1 

Protein Synonyms/Alias

 MsrB1; Selenoprotein R; SelR; Selenoprotein X; SelX 

Gene Name

 Msrb1 

Gene Synonyms/Alias

 Sepr; Sepx1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
61	SVTKCPEKNRPEALK	ubiquitination	[1]
68	KNRPEALKVSCGKCG	acetylation	[2, 3, 4]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

  

Sequence Annotation

 ACT_SITE 95 95 Nucleophile (By similarity).
 METAL 23 23 Zinc (By similarity).
 METAL 26 26 Zinc (By similarity).
 METAL 71 71 Zinc (By similarity).
 METAL 74 74 Zinc (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Oxidoreductase; Reference proteome; Selenocysteine; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 116 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0070191; F:methionine-R-sulfoxide reductase activity; IDA:MGI.
 GO:0033743; F:peptide-methionine (R)-S-oxide reductase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IDA:HGNC.
 GO:0030091; P:protein repair; IDA:HGNC. 

Interpro

 IPR002579; Met_Sox_Rdtase_MsrB.
 IPR011057; Mss4-like. 

Pfam

 PF01641; SelR 

SMART

  

PROSITE

  

PRINTS