UniProt Accession

 RMP_HUMAN; O94763; A8K805; H7BY42; Q8TC23; Q9UNU3 

Genbank Protein ID

 AF091095; AB006572; AK292170; AC008507; BC026184 

Genbank Nucleotide ID

 AAD08679.1; BAA34781.1; BAF84859.1; AAH26184.2 

Protein Name

 Unconventional prefoldin RPB5 interactor 1 

Protein Synonyms/Alias

 Protein NNX3; Protein phosphatase 1 regulatory subunit 19; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein 

Gene Name

 URI1 

Gene Synonyms/Alias

 C19orf2; NNX3; PPP1R19; RMP; URI 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
208	SKDLLADKELWARLE	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. 

Sequence Annotation

 MOD_RES 244 244 Phosphoserine (By similarity).
 MOD_RES 372 372 Phosphoserine; by RPS6KB1.
 MOD_RES 440 440 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Mitochondrion; Nucleus; Oncogene; Phosphoprotein; Polymorphism; Protein phosphatase inhibitor; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 535 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
 GO:0005665; C:DNA-directed RNA polymerase II, core complex; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0016272; C:prefoldin complex; IEA:InterPro.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
 GO:0001106; F:RNA polymerase II transcription corepressor activity; IDA:UniProtKB.
 GO:0071363; P:cellular response to growth factor stimulus; IDA:UniProtKB.
 GO:0071383; P:cellular response to steroid hormone stimulus; IDA:UniProtKB.
 GO:0010923; P:negative regulation of phosphatase activity; IMP:UniProtKB.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.
 GO:0001558; P:regulation of cell growth; IDA:UniProtKB.
 GO:0009615; P:response to virus; IMP:UniProtKB. 

Interpro

 IPR009053; Prefoldin.
 IPR004127; Prefoldin_subunit. 

Pfam

 PF02996; Prefoldin 

SMART

  

PROSITE

  

PRINTS