| Tag | Content |
|---|
| CPLM ID | CPLM-005431 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Periodic tryptophan protein 2 |
Protein Synonyms/Alias | U three protein 1; U3 small nucleolar RNA-associated protein 1; U3 snoRNA-associated protein 1 |
Gene Name | PWP2 |
Gene Synonyms/Alias | UTP1; YCR057C; YCR55C/YCR57C/YCR58C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 833 | RFIVRVAKEVVNTTT | ubiquitination | [1] | | 843 | VNTTTDNKYTYRFLV | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Required for bud-site selection and cell separation. Also involved in nucleolar processing of pre-18S ribosomal RNA. |
Sequence Annotation | REPEAT 12 52 WD 1.
REPEAT 53 93 WD 2.
REPEAT 94 132 WD 3.
REPEAT 144 183 WD 4.
REPEAT 189 228 WD 5.
REPEAT 258 297 WD 6.
REPEAT 300 340 WD 7.
REPEAT 343 382 WD 8.
REPEAT 385 424 WD 9.
REPEAT 428 470 WD 10.
REPEAT 471 510 WD 11.
REPEAT 513 552 WD 12.
REPEAT 575 614 WD 13.
REPEAT 676 714 WD 14.
MOD_RES 225 225 Phosphoserine.
MOD_RES 232 232 Phosphoserine.
MOD_RES 651 651 Phosphoserine.
MOD_RES 664 664 Phosphoserine.
MOD_RES 912 912 Phosphoserine.
MOD_RES 913 913 Phosphoserine. |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; Ribosome biogenesis; rRNA processing; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 923 AA |
Protein Sequence | MKSDFKFSNL LGTVYRQGNI TFSDDGKQLL SPVGNRVSVF DLINNKSFTF EYEHRKNIAA 60
IDLNKQGTLL ISIDEDGRAI LVNFKARNVL HHFNFKEKCS AVKFSPDGRL FALASGRFLQ 120
IWKTPDVNKD RQFAPFVRHR VHAGHFQDIT SLTWSQDSRF ILTTSKDLSA KIWSVDSEEK 180
NLAATTFNGH RDYVMGAFFS HDQEKIYTVS KDGAVFVWEF TKRPSDDDDN ESEDDDKQEE 240
VDISKYSWRI TKKHFFYANQ AKVKCVTFHP ATRLLAVGFT SGEFRLYDLP DFTLIQQLSM 300
GQNPVNTVSV NQTGEWLAFG SSKLGQLLVY EWQSESYILK QQGHFDSTNS LAYSPDGSRV 360
VTASEDGKIK VWDITSGFCL ATFEEHTSSV TAVQFAKRGQ VMFSSSLDGT VRAWDLIRYR 420
NFRTFTGTER IQFNCLAVDP SGEVVCAGSL DNFDIHVWSV QTGQLLDALS GHEGPVSCLS 480
FSQENSVLAS ASWDKTIRIW SIFGRSQQVE PIEVYSDVLA LSMRPDGKEV AVSTLKGQIS 540
IFNIEDAKQV GNIDCRKDII SGRFNQDRFT AKNSERSKFF TTIHYSFDGM AIVAGGNNNS 600
ICLYDVPNEV LLKRFIVSRN MALNGTLEFL NSKKMTEAGS LDLIDDAGEN SDLEDRIDNS 660
LPGSQRGGDL STRKMRPEVR VTSVQFSPTA NAFAAASTEG LLIYSTNDTI LFDPFDLDVD 720
VTPHSTVEAL REKQFLNALV MAFRLNEEYL INKVYEAIPI KEIPLVASNI PAIYLPRILK 780
FIGDFAIESQ HIEFNLIWIK ALLSASGGYI NEHKYLFSTA MRSIQRFIVR VAKEVVNTTT 840
DNKYTYRFLV STDGSMEDGA ADDDEVLLKD DADEDNEENE ENDVVMESDD EEGWIGFNGK 900
DNKLPLSNEN DSSDEEENEK ELP 923 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IDA:SGD. GO:0032040; C:small-subunit processome; IDA:SGD. GO:0030515; F:snoRNA binding; IPI:SGD. GO:0000910; P:cytokinesis; IMP:SGD. GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0030010; P:establishment of cell polarity; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |