CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041680
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Muscarinic acetylcholine receptor M4 
Protein Synonyms/Alias
 RCG26726 
Gene Name
 Chrm4 
Gene Synonyms/Alias
 rCG_26726 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
461LCNATFKKTFRHLLLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; G-protein coupled receptor; Membrane; Receptor; Reference proteome; Transducer; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 478 AA 
Protein Sequence
MANFTPVNGS SANQSVRLVT AAHNHLETVE MVFIATVTGS LSLVTVVGNI LVMLSIKVNR 60
QLQTVNNYFL FSLACADLII GAFSMNLYTL YIIKGYWPLG AVVCDLWLAL DYVVSNASVM 120
NLLIISFDRY FCVTKPLTYP ARRTTKMAGL MIAAAWVLSF VLWAPAILFW QFVVGKRTVP 180
DNQCFIQFLS NPAVTFGTAI AAFYLPVVIM TVLYIHISLA SRSRVHKHRP EGPKEKKAKT 240
LAFLKSPLMK PSIKKPPPGG ASREELRNGK LEEAPPPALP PPPRPVPDKD TSNESSSGSA 300
TQNTKERPPT ELSTAEATTP ALPAPTLQPR TLNPASKWSK IQIVTKQTGN ECVTAIEIVP 360
ATPAGMRPAA NVARKFASIA RNQVRKKRQM AARERKVTRT IFAILLAFIL TWTPYNVMVL 420
VNTFCQSCIP ERVWSIGYWL CYVNSTINPA CYALCNATFK KTFRHLLLCQ YRNIGTAR 478 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0016907; F:G-protein coupled acetylcholine receptor activity; IEA:Compara.
 GO:0007197; P:adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway; IEA:Compara.
 GO:0014056; P:regulation of acetylcholine secretion; IEA:InterPro.
 GO:0040012; P:regulation of locomotion; IEA:InterPro.
 GO:0010033; P:response to organic substance; IEA:InterPro. 
Interpro
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR001432; Musac_Ach_M4_rcpt.
 IPR000995; Musac_Ach_rcpt. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00237; GPCRRHODOPSN.
 PR00243; MUSCARINICR.
 PR00541; MUSCRINICM4R.