UniProt Accession

 HUTI_HUMAN; Q96NU7; A8K463; Q68CI8 

Genbank Protein ID

 AK054617; AK290828; AB075878; AC126174; CH471054; BC029146 

Genbank Nucleotide ID

 BAB70775.1; BAF83517.1; BAD38660.1; EAW97552.1; AAH29146.1 

Protein Name

 Probable imidazolonepropionase 

Protein Synonyms/Alias

 Amidohydrolase domain-containing protein 1 

Gene Name

 AMDHD1 

Gene Synonyms/Alias

 HMFT1272 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	VGKDGFIKAIGPADV	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 METAL 87 87 Zinc or iron (By similarity).
 METAL 89 89 Zinc or iron (By similarity).
 METAL 260 260 Zinc or iron (By similarity).
 METAL 334 334 Zinc or iron (By similarity).
 BINDING 96 96 Substrate (By similarity).
 BINDING 109 109 Substrate (By similarity).
 BINDING 159 159 Substrate (By similarity).
 BINDING 192 192 Substrate (By similarity).
 BINDING 263 263 Substrate (By similarity).  

Keyword

 Complete proteome; Histidine metabolism; Hydrolase; Iron; Metal-binding; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 426 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0050480; F:imidazolonepropionase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006548; P:histidine catabolic process; TAS:Reactome.
 GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
 GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway. 

Interpro

 IPR005920; HutI.
 IPR011059; Metal-dep_hydrolase_composite. 

Pfam

  

SMART

  

PROSITE

  

PRINTS