UniProt Accession

 H7C440_HUMAN; H7C440 

Genbank Protein ID

 AC013435; AC019130; AC068134; AC093374; AC105461; AC138658 

Genbank Nucleotide ID

  

Protein Name

 DIS3-like exonuclease 2 

Protein Synonyms/Alias

  

Gene Name

 DIS3L2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	SKRRDLRKDCIFTID	ubiquitination	[1]
32	LDDALSCKPLADGNF	ubiquitination	[1]
142	MIESPTEKIPAKELP	ubiquitination	[2]
231	ANMAVAHKIHRAFPE	ubiquitination	[1]
287	TQTFGDDKYSLARKE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 383 AA 

Protein Sequence

Gene Ontology

 GO:0004540; F:ribonuclease activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro. 

Interpro

 IPR001900; RNase_II/R.
 IPR022966; RNase_II/R_CS. 

Pfam

 PF00773; RNB 

SMART

 SM00955; RNB 

PROSITE

 PS01175; RIBONUCLEASE_II 

PRINTS