UniProt Accession

 RRP36_HUMAN; Q96EU6; Q9BRF6; Q9P0C8 

Genbank Protein ID

 AL136304; BC006293; BC011933; AF161371 

Genbank Nucleotide ID

 CAI19798.1; AAH06293.2; AAH11933.1; AAF28931.1 

Protein Name

 Ribosomal RNA processing protein 36 homolog 

Protein Synonyms/Alias

  

Gene Name

 RRP36 

Gene Synonyms/Alias

 C6orf153; HSPC253 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
115	QVVPISKKVARDPRF	ubiquitination	[1]
225	RQLALAEKFKELKRS	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. 

Sequence Annotation

 MOTIF 241 244 Nuclear localization signal (Potential).
 MOD_RES 73 73 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ribosome biogenesis; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0042274; P:ribosomal small subunit biogenesis; IDA:UniProtKB.
 GO:0006364; P:rRNA processing; IDA:UniProtKB. 

Interpro

 IPR009292; DUF947. 

Pfam

 PF06102; DUF947 

SMART

  

PROSITE

  

PRINTS