CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002085
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gastricsin 
Protein Synonyms/Alias
 Pepsinogen C 
Gene Name
 Pgc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
34KSIRETMKEQGVLKDacetylation[1]
40MKEQGVLKDFLKTHKacetylation[1]
44GVLKDFLKTHKYDPGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Hydrolyzes a variety of proteins. 
Sequence Annotation
 ACT_SITE 94 94
 ACT_SITE 280 280
 DISULFID 107 112 By similarity.
 DISULFID 270 275 By similarity.
 DISULFID 314 347 By similarity.  
Keyword
 Aspartyl protease; Complete proteome; Digestion; Direct protein sequencing; Disulfide bond; Hydrolase; Protease; Reference proteome; Secreted; Signal; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 392 AA 
Protein Sequence
MKWMVVALLC LPLLEASLLR VPLRKMKSIR ETMKEQGVLK DFLKTHKYDP GQKYHFGNFG 60
DYSVLYEPMA YMDASYFGEI SIGTPPQNFL VLFDTGSSNL WVSSVYCQSE ACTTHARFNP 120
SKSSTYYTEG QTFSLQYGTG SLTGFFGYDT LTVQSIQVPN QEFGLSENEP GTNFVYAQFD 180
GIMGLAYPGL SSGGATTALQ GMLGEGALSQ PLFGVYLGSQ QGSNGGQIVF GGVDKNLYTG 240
EITWVPVTQE LYWQITIDDF LIGDQASGWC SSQGCQGIVD TGTSLLVMPA QYLSELLQTI 300
GAQEGEYGEY FVSCDSVSSL PTLSFVLNGV QFPLSPSSYI IQEDNFCMVG LESISLTSES 360
GQPLWILGDV FLRSYYAIFD MGNNKVGLAT SV 392 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0007586; P:digestion; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001461; Peptidase_A1.
 IPR021109; Peptidase_aspartic.
 IPR001969; Peptidase_aspartic_AS.
 IPR012848; Propep_A1. 
Pfam
 PF07966; A1_Propeptide
 PF00026; Asp 
SMART
  
PROSITE
 PS00141; ASP_PROTEASE 
PRINTS
 PR00792; PEPSIN.