UniProt Accession

 LTOR4_HUMAN; Q0VGL1 

Genbank Protein ID

 CH471091; BC063401; BC105609; BC130553; BC130559 

Genbank Nucleotide ID

 EAW76585.1; AAH63401.1; AAI05610.1; AAI30554.1; AAI30560.1 

Protein Name

 Ragulator complex protein LAMTOR4 

Protein Synonyms/Alias

 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 

Gene Name

 LAMTOR4 

Gene Synonyms/Alias

 C7orf59 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
64	RGMNVPFKRLSVVFG	ubiquitination	[1]
88	GQRVFVVKRQNRGRE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. 

Sequence Annotation

 MOD_RES 2 2 N-acetylthreonine.  

Keyword

 Acetylation; Complete proteome; Lysosome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 99 AA 

Protein Sequence

Gene Ontology

 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0071986; C:Ragulator complex; IDA:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; IMP:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; IMP:UniProtKB.
 GO:0061462; P:protein localization to lysosome; IMP:UniProtKB.
 GO:0008361; P:regulation of cell size; IMP:UniProtKB. 

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