CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010376
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 DNA-directed RNA polymerase subunit beta 
Protein Synonyms/Alias
 RNAP subunit beta; RNA polymerase subunit beta; Transcriptase subunit beta 
Gene Name
 rpoB 
Gene Synonyms/Alias
 MPN_516; MP326 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
10QKPSFFQKKYSPTATacetylation[1]
273NNVDPEIKNLLREFRacetylation[1]
318HKALSEAKPNDPKVGacetylation[1]
825APCSGTVKYVDNSKIacetylation[1]
872EKGQRVTKDEVIADGacetylation[1]
993VEVSPEEKLFKAIFPacetylation[1]
996SPEEKLFKAIFPESVacetylation[1]
1058RKIQIGDKLAGRHGNacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome; Transcription; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1391 AA 
Protein Sequence
MSQKPSFFQK KYSPTATRRY YGKIATDFVQ PNLADIQIRS YQTFLDHDLE NLIAAYFPIK 60
SPNDRYTINF KGLRRTAPER NEAQSRSESK TYEIGIYADL ELIDSATGTI KKPRKSKKNS 120
ATSSVDGVFL TNLPLITRDG VFIVNGIEKF VIAQITRSPG IYMLTKSQLK LSSSRKRVQE 180
GYVCEVLPAN GSVMLIYISN KKKIEDAFVQ ILLRDAVREG AKIFPITTLL KAFGMSGKEI 240
LKVFKNNEFI TRSLEAEVYN AKDFLNNVDP EIKNLLREFR DGKTDLRRKG IASDQKIRSL 300
VSDYVLLEKE HKALSEAKPN DPKVGQLEAD MDELMDKIIT ERAAKHIVHE LSISLRGLEN 360
TDECPENSYH ALLCSRFFRQ RRYNLSAAGR YKVSRKLRIT ERIYQKTLAC DLHLKNGELL 420
LKKGTLLVKE EIDKIKQAAQ NNQIDFVQKI KLTTDGSAVN LSPESLLYES LDVYVNNDNF 480
DVSVPVVGIH NDNDLNKAIT LSDFIASISY VINIPSAIGK YDDIDHLGNK RVKLINELIS 540
SRLESGITRM ERFLKEKLTI ADGVNRGQQI NEEGQVIEQA EKKELTIKSL INSKPIQIVI 600
RDFFNTHQLT QFLDHQNPLS ELSNKRRISA MGPGGISRED PNLDIRDVHY SQYGRICPIE 660
TPEGMNIGLI MSLASFAKID ENGFLMAPYR KIKNGVITDE VEYLTALRED EHIIAEISSL 720
VNIDENNKIL DKEIIGRYRS MQGLYDPSKI DYIDVAPHQV VSIGSSLIPF LENDDSARAL 780
MGTNMQRQAY PLIKPYAPVV GTGQEYKIAR DSGLTMLAPC SGTVKYVDNS KITIESDSGE 840
QHTLDLIKFE RSNQNTCYNH VPLVEKGQRV TKDEVIADGP AVNKSELSLG QNVLVAFTTW 900
NGYNYEDAIV ISERLVKDDV LTSLTINEYV AQCLSTKNGD EQITRDIPNV SDANKRYLDE 960
NGIIMVGAEV KEGDVLVGKV SPKGQVEVSP EEKLFKAIFP ESVQNVRDSS LKLPHGGDGI 1020
VSCVKRFSIA NGNELNDGVI EMIKVYVVQK RKIQIGDKLA GRHGNKGVIS KVVPVADMPH 1080
LEDGTPVDIL LNPLGVPSRM NIGQIFEMHL GYAAHNLAKR MLISACFDDK KAQALSTEIN 1140
QPQYKLDRLI TGLKAQITNR GLKDEQAALA QLNNGDIALV LKEIGMSFDD LHFKVATPIF 1200
QGVNFQDLQD IMDEAGLKPA ETHGKFKLID GRTGLPFEKP ISLGIMYIMK LNHMVDDKIH 1260
ARAVGPYSKI TQQPLGGKSQ NGGQRFGEME VWALEAYGAA YNLQELLTIK SDDVQGRNKA 1320
YAAIVKGAAF PEPGIPESFK LLTKELQGLA LSVSFIYDDN TQQDSNNVSI LQADGEQDDL 1380
FNDFEFDTEG Y 1391 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:HAMAP.
 GO:0032549; F:ribonucleoside binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:HAMAP. 
Interpro
 IPR010243; DNA-dir_RNA_pol_bsu.
 IPR019462; DNA-dir_RNA_pol_bsu_external_1.
 IPR015712; DNA-dir_RNA_pol_su2.
 IPR007120; DNA-dir_RNA_pol_su2_6.
 IPR007121; RNA_pol_bsu_CS.
 IPR007644; RNA_pol_bsu_protrusion.
 IPR007642; RNA_pol_Rpb2_2.
 IPR007645; RNA_pol_Rpb2_3.
 IPR007641; RNA_pol_Rpb2_7.
 IPR014724; RNA_pol_RPB2_OB-fold. 
Pfam
 PF04563; RNA_pol_Rpb2_1
 PF04565; RNA_pol_Rpb2_3
 PF10385; RNA_pol_Rpb2_45
 PF00562; RNA_pol_Rpb2_6
 PF04560; RNA_pol_Rpb2_7 
SMART
  
PROSITE
 PS01166; RNA_POL_BETA 
PRINTS