CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023302
UniProt Accession
Genbank Protein ID
 AB020627; AL136712; AL031864; AL121984; AL133514; AL137157; AL445990; AL512843; Z97195; AL121984; AL031864; AL133514; AL137157; AL445990; AL512843; Z97195; AL133514; AL031864; AL121984; AL137157; AL445990; AL512843; Z97195; AL137157; AL031864; AL121984; AL133514; AL445990; AL512843; Z97195; AL445990; AL031864; AL121984; AL133514; AL137157; AL512843; Z97195; AL445990; AL031864; AL121984; AL133514; AL137157; AL512843; Z97195; AL512843; AL031864; AL121984; AL133514; AL137157; AL445990; Z97195; AL512843; AL031864; AL121984; AL133514; AL137157; AL445990; Z97195; AL121984; AL031864; AL133514; AL137157; AL445990; AL512843; Z97195; AL133514; AL031864; AL121984; AL137157; AL445990; AL512843; Z97195; Z97195; AL031864; AL121984; AL133514; AL137157; AL445990; AL512843; Z97195; AL031864; AL121984; AL133514; AL137157; AL445990; AL512843; AL137157; AL031864; AL121984; AL133514; AL445990; AL512843; Z97195; AL031864; AL121984; AL133514; AL137157; AL445990; AL512843; Z97195 
Genbank Nucleotide ID
 BAA74843.2; CAB66647.1; CAI22007.1; CAI22007.1; CAI22007.1; CAI22007.1; CAI22007.1; CAI22007.1; CAI22007.1; CAH71952.1; CAH71952.1; CAH71952.1; CAH71952.1; CAH71952.1; CAH71952.1; CAH71952.1; CAH74079.1; CAH74079.1; CAH74079.1; CAH74079.1; CAH74079.1; CAH74079.1; CAH74079.1; CAI19211.1; CAI19211.1; CAI19211.1; CAI19211.1; CAI19211.1; CAI19211.1; CAI19211.1; CAH69969.1; CAH69969.1; CAH69969.1; CAH69969.1; CAH69969.1; CAH69969.1; CAH69969.1; CAH69970.1; CAH69970.1; CAH69970.1; CAH69970.1; CAH69970.1; CAH69970.1; CAH69970.1; CAH71040.1; CAH71040.1; CAH71040.1; CAH71040.1; CAH71040.1; CAH71040.1; CAH71040.1; CAH71041.1; CAH71041.1; CAH71041.1; CAH71041.1; CAH71041.1; CAH71041.1; CAH71041.1; CAH71951.1; CAH71951.1; CAH71951.1; CAH71951.1; CAH71951.1; CAH71951.1; CAH71951.1; CAH74080.1; CAH74080.1; CAH74080.1; CAH74080.1; CAH74080.1; CAH74080.1; CAH74080.1; CAI19054.1; CAI19054.1; CAI19054.1; CAI19054.1; CAI19054.1; CAI19054.1; CAI19054.1; CAI19055.1; CAI19055.1; CAI19055.1; CAI19055.1; CAI19055.1; CAI19055.1; CAI19055.1; CAI19212.1; CAI19212.1; CAI19212.1; CAI19212.1; CAI19212.1; CAI19212.1; CAI19212.1; CAI22008.1; CAI22008.1; CAI22008.1; CAI22008.1; CAI22008.1; CAI22008.1; CAI22008.1 
Protein Name
 Dynamin-3 
Protein Synonyms/Alias
 Dynamin, testicular; T-dynamin 
Gene Name
 DNM3 
Gene Synonyms/Alias
 KIAA0820 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
541ISNIGIMKGGSKGYWacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). 
Sequence Annotation
 DOMAIN 515 621 PH.
 DOMAIN 659 750 GED.
 NP_BIND 38 45 GTP (By similarity).
 NP_BIND 136 140 GTP (By similarity).
 NP_BIND 205 208 GTP (By similarity).
 MOD_RES 769 769 Phosphoserine (By similarity).
 MOD_RES 773 773 Phosphoserine (By similarity).
 MOD_RES 853 853 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Endocytosis; GTP-binding; Hydrolase; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 869 AA 
Protein Sequence
MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 60
SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRLE IEAETDRVTG MNKGISSIPI 120
NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIREMI MQFITRENCL ILAVTPANTD 180
LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 240
DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 300
QGQLLSIEHE VEAYKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 360
KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 420
KGPSLKSVDL VIQELINTVK KCTKKLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 480
IQVSYINTNH EDFIGFANAQ QRSSQVHKKT TVGNQGTNLP PSRQIVIRKG WLTISNIGIM 540
KGGSKGYWFV LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKSFMSSKH IFALFNTEQR 600
NVYKDYRFLE LACDSQEDVD SWKASLLRAG VYPDKSVAEN DENGQAENFS MDPQLERQVE 660
TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKDFINSE LLAQLYSSED QNTLMEESAE 720
QAQRRDEMLR MYQALKEALG IIGDISTATV STPAPPPVDD SWIQHSRRSP PPSPTTQRRP 780
TLSAPLARPT SGRGPAPAIP SPGPHSGAPP VPFRPGPLPP FPSSSDSFGA PPQVPSRPTR 840
APPSVPSRRP PPSPTRPTII RPLESSLLD 869 
Gene Ontology
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0014069; C:postsynaptic density; ISS:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0006897; P:endocytosis; ISS:UniProtKB.
 GO:0046847; P:filopodium assembly; ISS:UniProtKB.
 GO:0007416; P:synapse assembly; ISS:UniProtKB. 
Interpro
 IPR022812; Dynamin.
 IPR000375; Dynamin_central.
 IPR001401; Dynamin_GTPase.
 IPR019762; Dynamin_GTPase_CS.
 IPR003130; GED.
 IPR020850; GTPase_effector_domain_GED.
 IPR027417; P-loop_NTPase.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF01031; Dynamin_M
 PF00350; Dynamin_N
 PF02212; GED
 PF00169; PH 
SMART
 SM00053; DYNc
 SM00302; GED
 SM00233; PH 
PROSITE
 PS00410; DYNAMIN
 PS51388; GED
 PS50003; PH_DOMAIN 
PRINTS
 PR00195; DYNAMIN.