CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015981
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pleckstrin homology domain-containing family H member 3 
Protein Synonyms/Alias
 PH domain-containing family H member 3 
Gene Name
 PLEKHH3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
87TWSLIPEKGLPEDDPubiquitination[1]
137DQFSSSGKGARRLGSubiquitination[1]
201LREVIASKAPLETPTubiquitination[1]
310ELFLQLAKQTSGPAGubiquitination[1]
632AAVLGGWKRLRGMGRubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 DOMAIN 95 199 PH.
 DOMAIN 237 399 MyTH4.
 DOMAIN 404 754 FERM.
 MOD_RES 30 30 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 793 AA 
Protein Sequence
MPLPGGLWWL LCCRRGFTLL HRDYGDGELS GDGDEDEDEE TFELRTPSPA GGGRGPLEVT 60
LTQPVRSGPV SNRLQSWEET WSLIPEKGLP EDDPDIVVKG WLYREPRGGG ARPWLPPRRA 120
WFVLTRDSLD QFSSSGKGAR RLGSLVLTSL CSVTGPERRR KETGLWSVTV SGRKHSVRLC 180
SPRQAEAERW GVALREVIAS KAPLETPTQL LLRDIQESCG DPEAVALIYL RNPILRHTSG 240
ALYAPLLPLP YGVSAPGPGY APLREEAVRL FLALQALEGA RRPGPLMQGV LQTCRDLPAL 300
RDELFLQLAK QTSGPAGPPG LPATQDPAAL RYWQLLTCMS CTFRPGGAVR GHLLGHLERT 360
EQALPDSELA EYARFIRKAL GRTRGRELVP SLAEISALSQ RQELLCTVHC PGAGACAVAI 420
DSHTTAGEVA RELVGRLGLA RSRNAFALYE QRGAQERALA GGTLVADVLT SLAAEEAGLE 480
DSPDSGWRLC LRLHGPLHPE GLSPDGHELP FLFEQAHALL LRGRPPPPDD TLRALAALRL 540
QSLQRDFSPR VPLPRLDRLL PPPAPPREDP PRPTPRPPPS AALLAGALWS PGLAKRRAER 600
ARRGGAGRTA GSIAREGGGG AGTAAAVLGG WKRLRGMGRA EAMAAYLALA AQCPGFGAAR 660
YDVLELSTVR GRREKGTLAA QAPHLCPRAT GPTECHVIPH IQNSYPSQTP GVTSPWALTS 720
LEPQPPPHTC CES 733 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR019749; Band_41_domain.
 IPR019748; FERM_central.
 IPR000299; FERM_domain.
 IPR000857; MyTH4_dom.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000159; Ras-assoc. 
Pfam
 PF00784; MyTH4
 PF00788; RA 
SMART
 SM00295; B41
 SM00233; PH 
PROSITE
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3
 PS51016; MYTH4
 PS50003; PH_DOMAIN 
PRINTS