| Tag | Content |
|---|
| CPLM ID | CPLM-021204 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Caseinolytic peptidase B protein homolog |
Protein Synonyms/Alias | Suppressor of potassium transport defect 3 |
Gene Name | CLPB |
Gene Synonyms/Alias | HSP78; SKD3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 163 | EGADVNAKHRLGWTA | ubiquitination | [1] | | 283 | AREGEVMKLLRTSEA | ubiquitination | [1] | | 411 | EEGGQLTKKLKQCPN | ubiquitination | [1] | | 412 | EGGQLTKKLKQCPNA | ubiquitination | [1] | | 559 | KELNFWAKRAKQRHN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May function as a regulatory ATPase and be related to secretion/protein trafficking process. |
Sequence Annotation | REPEAT 133 162 ANK 1.
REPEAT 166 195 ANK 2.
REPEAT 265 295 ANK 3.
REPEAT 298 327 ANK 4.
NP_BIND 381 388 ATP (Potential).
MOD_RES 589 589 N6-acetyllysine. |
Keyword | Acetylation; Alternative splicing; ANK repeat; ATP-binding; Complete proteome; Nucleotide-binding; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 707 AA |
Protein Sequence | MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV ATGGRPGTSP 60
ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG QDSWNGVPSR AGLGMCALAA 120
ALVVHCYSKS PSNKDAALLE AARANNMQEV SRLLSEGADV NAKHRLGWTA LMVAAINRNN 180
SVVQVLLAAG ADPNLGDDFS SVYKTAKEQG IHSLEVLITR EDDFNNRLNN RASFKGCTAL 240
HYAVLADDYR TVKELLDGGA NPLQRNEMGH TPLDYAREGE VMKLLRTSEA KYQEKQRKRE 300
AEERRRFPLE QRLKEHIIGQ ESAIATVGAA IRRKENGWYD EEHPLVFLFL GSSGIGKTEL 360
AKQTAKYMHK DAKKGFIRLD MSEFQERHEV AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV 420
VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK GKTIDCKDAI FIMTSNVASD EIAQHALQLR 480
QEALEMSRNR IAENLGDVQI SDKITISKNF KENVIRPILK AHFRRDEFLG RINEIVYFLP 540
FCHSELIQLV NKELNFWAKR AKQRHNITLL WDREVADVLV DGYNVHYGAR SIKHEVERRV 600
VNQLAAAYEQ DLLPGGCTLR ITVEDSDKQL LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR 660
RLDIRAPLHP EKVCNTI 677 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0034605; P:cellular response to heat; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |