CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021078
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prolargin 
Protein Synonyms/Alias
 Proline-arginine-rich end leucine-rich repeat protein 
Gene Name
 Prelp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
208RLSDGVFKADTFQGLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May anchor basement membranes to the underlying connective tissue (By similarity). 
Sequence Annotation
 REPEAT 90 109 LRR 1.
 REPEAT 110 133 LRR 2.
 REPEAT 134 157 LRR 3.
 REPEAT 158 178 LRR 4.
 REPEAT 179 202 LRR 5.
 REPEAT 203 228 LRR 6.
 REPEAT 229 249 LRR 7.
 REPEAT 250 273 LRR 8.
 REPEAT 274 298 LRR 9.
 REPEAT 299 318 LRR 10.
 REPEAT 319 357 LRR 11.
 REPEAT 358 377 LRR 12.
 CARBOHYD 119 119 N-linked (GlcNAc...) (Potential).
 CARBOHYD 284 284 N-linked (GlcNAc...) (Potential).
 CARBOHYD 315 315 N-linked (GlcNAc...) (Potential).
 CARBOHYD 322 322 N-linked (GlcNAc...) (Potential).
 DISULFID 327 368 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MRASFFWFLP LLLILASVAQ GQPRPKPGIR RKPKPRPTPS FPQPHEPAEP TDLPPPLPPG 60
PPSVFPDCPR ECYCPPDFPS ALYCDSRNLR KVPIIPPRIH YLYLQNNFIT ELPVESFKNA 120
TGLRWINLDN NRIRKVDQRV LEKLPGLAFL YMDKNQLEEV PSALPRNLEQ LRLSQNLISR 180
IPPGVFSKLE NLLLLDLQHN RLSDGVFKAD TFQGLKNLMQ LNLAHNILRR MPPKVPPAIH 240
QLYLDSNKIE TIPSGYFKDF PNLAFIRMNY NKLSDRGLPK NSFNISNLLV LHLSHNKISN 300
VPAISNKLEH LYLNNNSIEK INGTQICPSN LVAFHDFSSD LENVPHLRYL RLDGNFLKPP 360
IPLDLMMCFR LLQSVVI 377 
Gene Ontology
 GO:0005578; C:proteinaceous extracellular matrix; TAS:RGD.
 GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
 GO:0008201; F:heparin binding; IDA:RGD.
 GO:0007569; P:cell aging; IEA:Compara. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR000372; LRR-contain_N.
 IPR027216; Prolargin. 
Pfam
 PF00560; LRR_1
 PF01462; LRRNT 
SMART
 SM00013; LRRNT 
PROSITE
 PS51450; LRR 
PRINTS