CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004787
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homeobox protein engrailed-2 
Protein Synonyms/Alias
 Homeobox protein en-2; Hu-En-2 
Gene Name
 EN2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
245KNPNKEDKRPRTAFTmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
  
Sequence Annotation
 DNA_BIND 244 303 Homeobox.  
Keyword
 Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 333 AA 
Protein Sequence
MEENDPKPGE AAAAVEGQRQ PESSPGGGSG GGGGSSPGEA DTGRRRALML PAVLQAPGNH 60
QHPHRITNFF IDNILRPEFG RRKDAGTCCA GAGGGRGGGA GGEGGASGAE GGGGAGGSEQ 120
LLGSGSREPR QNPPCAPGAG GPLPAAGSDS PGDGEGGSKT LSLHGGAKKG GDPGGPLDGS 180
LKARGLGGGD LSVSSDSDSS QAGANLGAQP MLWPAWVYCT RYSDRPSSGP RSRKPKKKNP 240
NKEDKRPRTA FTAEQLQRLK AEFQTNRYLT EQRRQSLAQE LSLNESQIKI WFQNKRAKIK 300
KATGNKNTLA VHLMAQGLYN HSTTAKEGKS DSE 333 
Gene Ontology
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0030902; P:hindbrain development; IEA:Compara.
 GO:0030901; P:midbrain development; IEA:Compara.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR019549; Homeobox-engrailed_C-terminal.
 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR000747; Homeodomain_engrailed.
 IPR019737; Homoebox-engrailed_CS. 
Pfam
 PF10525; Engrail_1_C_sig
 PF00046; Homeobox 
SMART
 SM00389; HOX 
PROSITE
 PS00033; ENGRAILED
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS
 PR00026; ENGRAILED.
 PR00024; HOMEOBOX.