CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034227
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tripartite motif-containing protein 59 
Protein Synonyms/Alias
  
Gene Name
 Trim59 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
182EKIVQGDKEVVLQYFacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 389 AA 
Protein Sequence
MHNFEEELTC PICYSIFEDP RVLPCSHTFC RNCLENVLQA SGNFYIWRPL RIPLKCPNCR 60
SIIEIASTGI ESLPVNFALR AIIEKYQQED HPDVVTCPEH YRQPLNVYCL LDKKLVCGHC 120
LTIGQHHGHP IDDLQSAYLK EKDTPQKLLK QLTDTHWTDI TRLIEKLEEQ KCHSEKIVQG 180
DKEVVLQYFK ELIDTLEQKK KYFLAALCDV GKMINQEYTP QIQGMKEIRE QQLELMTITT 240
SLQDESPLKF LEKIDEVRQR VQMLKQRPLP EVQPVEIYPR VSNVLKEEWS RIEIGRIKKA 300
VIPEMRVSSK RTPCSWSDND EKEMELFKIL NIAIVSLISV ILMLILLFNH HIITFLNEIT 360
SICFSEVFLS VYQSLSKNLY DLNNTVCYT 389 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:MGI. 
Interpro
 IPR000315; Znf_B-box.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00643; zf-B_box 
SMART
 SM00184; RING 
PROSITE
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS