CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024381
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AT-rich interactive domain-containing protein 4B 
Protein Synonyms/Alias
 ARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p180; Histone deacetylase complex subunit SAP180 
Gene Name
 Arid4b 
Gene Synonyms/Alias
 Sap180 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
906GFSEVAEKRIKLLNNacetylation[1, 2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). 
Sequence Annotation
 DOMAIN 306 398 ARID.
 MOD_RES 276 276 Phosphoserine (By similarity).
 MOD_RES 666 666 Phosphoserine (By similarity).
 MOD_RES 675 675 Phosphoserine (By similarity).
 MOD_RES 717 717 Phosphoserine (By similarity).
 MOD_RES 778 778 Phosphoserine (By similarity).
 MOD_RES 790 790 Phosphoserine (By similarity).
 MOD_RES 793 793 Phosphothreonine (By similarity).
 MOD_RES 1016 1016 Phosphoserine (By similarity).
 MOD_RES 1028 1028 Phosphothreonine (By similarity).
 MOD_RES 1152 1152 Phosphothreonine (By similarity).
 MOD_RES 1154 1154 Phosphoserine (By similarity).
 MOD_RES 1155 1155 Phosphoserine (By similarity).
 MOD_RES 1157 1157 Phosphoserine (By similarity).
 MOD_RES 1161 1161 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1314 AA 
Protein Sequence
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE VQDDHIKGPL 60
KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT LRRSSLCLKG ERHFAESETL 120
DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP EEESSSSSSD DDEEERKQTD ELLGKVVCVD 180
YVSLEKKKAM WFPALVVCPD CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTVPK 240
PDAVLKQAFD QALEFHKSRA IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE 300
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL GGFDNIESGA 360
VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA NIDFQMALPE KVLNKPCKDC 420
ENKEVKVKEE SETEIKEVNV EDSKNVMPKE ETPAEDESER KENIKPSLGS KKSLLECIPA 480
QSDEEKEAHI TKLEENENLE DKDGGRARTE EAFSTEVDGE EEQARSGDET NKEEDEDDEE 540
IEEEEEEDEE EDEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG 600
EALYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD RDEKYSPKNC 660
KLRRLSKSPF QSNPSPEMVS KLDLADAKNS DTAHIKSIEI TSILNGLQAS ESSAEDSEQE 720
DERCTQDVDN IGKDESKVEH STHSRNELIS KEEQSSPSLL EENKVHTDLV IAKTVSKSPE 780
RLRKDMEAIS EDTDFEEEDE ITKKRKDVKK DTTDKALKPQ TKRGKRRYCS ADECLQTGSP 840
GKKEDRTKSK EPLCTENSSN SSSDEDEEEK SKAKMTPTKK YNGLEEKRKS LRTTSFYSGF 900
SEVAEKRIKL LNNSDERLQN NRAKDRKDVW SSIQGQWPKK TLKELFSDSD TEAAASPPHP 960
APDEGAVEES LQTVAEEESC SPIMELEKPL PASVDNKPIE EKPLEVSDRK TEFPSSGSNS 1020
VLNTPPTTPE SPSSVTITEA SQQQSSVTVS VPLPPNQEEV RSIKSETDST IEVDSVVGEL 1080
QDLQSEGNSS PAGFDASVSS SSSNQPEPDN PEKACTGQKR VKDTQGVGSS SKKQKRSHKA 1140
TVVNNKKKGK GTNSSDSEEL SAGESVTKTQ TIKSVPTGMK THNSKSPARV QSPGKGGRNG 1200
DKDPDLKEPS NRLPKVYKWS FQTSDLENMT SAERISILQE KLQEIRKHYL SLKSEVASID 1260
RRRKRLKKKE RESAATSSSS SSPSSSSITA AVMLTLAEPS MSSASQNGMS VECR 1314 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0036124; P:histone H3-K9 trimethylation; IGI:MGI.
 GO:0034773; P:histone H4-K20 trimethylation; IGI:MGI.
 GO:0006349; P:regulation of gene expression by genetic imprinting; IGI:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001606; ARID/BRIGHT_DNA-bd.
 IPR000953; Chromo_domain/shadow.
 IPR016197; Chromodomain-like.
 IPR012603; RBB1NT.
 IPR002999; Tudor.
 IPR025995; Tudor-knot. 
Pfam
 PF01388; ARID
 PF08169; RBB1NT
 PF11717; Tudor-knot 
SMART
 SM00501; BRIGHT
 SM00298; CHROMO
 SM00333; TUDOR 
PROSITE
 PS51011; ARID 
PRINTS