| Tag | Content |
|---|
| CPLM ID | CPLM-022734 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 |
Protein Synonyms/Alias | Lysyl hydroxylase 1; LH1 |
Gene Name | Plod1 |
Gene Synonyms/Alias | Plod |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 402 | RLLIEQNKNVIAPLM | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. |
Sequence Annotation | DOMAIN 637 728 Fe2OG dioxygenase.
ACT_SITE 719 719 Potential.
METAL 657 657 Iron (By similarity).
METAL 659 659 Iron (By similarity).
METAL 709 709 Iron (By similarity).
CARBOHYD 198 198 N-linked (GlcNAc...).
CARBOHYD 539 539 N-linked (GlcNAc...) (Potential).
CARBOHYD 687 687 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Dioxygenase; Endoplasmic reticulum; Glycoprotein; Iron; Membrane; Metal-binding; Oxidoreductase; Reference proteome; Signal; Vitamin C. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 728 AA |
Protein Sequence | MRSLLLLAPL AWLLLVQAKD DAKLEDNLLV LTVATKETEG FRRFKRSAQF FNYKIQSLGL 60
GEDWSVDGGP AAAGGGQKVR LLKKALEKHA DKEDLVILFV DSYDVVFASG PRELLKKFQQ 120
AKSQVVFSAE EHIYPDRRLE AKYPTVPDGK RFLGSGGFIG YAPSLSKLVA EWEGQDSDSD 180
QLFYTKIFLN PEKREQINIS LDHRCRIFQN LDGALDEVVL KFEMGHVRAR NLAYDTLPVV 240
VHGNGPTKLQ LNYLGNYIPR FWTFETGCTV CDEGLRSLKG IGDEALPTVL VGVFIEQPTP 300
FLSLFFLRLL RLRYPQKQMR LFIHNQERHH KLQVEQFLAE HGSEYQSVKL VGPEVRMANA 360
DARNMGADLC RQDQTCTYYF SVDADVALTE PNSLRLLIEQ NKNVIAPLMT RHGRLWSNFW 420
GGLSADGYYA RSEDYVDIVQ GRRVGVWNVP YISNIYLIKG SALRAELQNV DLFHYSKLDS 480
DMSFCANVRQ QEVFMFLTNR HTFGHLLSLD NYQTTHLHND LWEVFSNPED WKEKYIHENY 540
TKALAGKLVE TPCPDVYWFP IFTEAACDEL VEEMEHYGQW SLGDNKDNRI QGGYENVPTI 600
DIHMNQITFE REWHKFLVEY IAPMTEKLYP GYYTRAQFDL AFVVRYKPDE QPSLMPHHDA 660
STFTVNIALN RVGEDYEGGG CRFLRYNCSV RAPRKGWALL HPGRLTHYHE GLPTTKGTRY 720
IAVSFVDP 728 |
Gene Ontology | GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW. GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. GO:0008475; F:procollagen-lysine 5-dioxygenase activity; IEA:EC. GO:0001666; P:response to hypoxia; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |