| Tag | Content |
|---|
| CPLM ID | CPLM-019298 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Centromere protein N |
Protein Synonyms/Alias | CENP-N; Interphase centromere complex protein 32 |
Gene Name | CENPN |
Gene Synonyms/Alias | C16orf60; ICEN32; BM-309 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 102 | DVDLFDMKQFKNSFK | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. |
Sequence Annotation | MOD_RES 226 226 Phosphoserine.
MOD_RES 282 282 Phosphoserine. |
Keyword | Alternative splicing; Centromere; Chromosome; Complete proteome; Kinetochore; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 339 AA |
Protein Sequence | MDETVAEFIK RTILKIPMNE LTTILKAWDF LSENQLQTVN FRQRKESVVQ HLIHLCEEKR 60
ASISDAALLD IIYMQFHQHQ KVWEVFQMSK GPGEDVDLFD MKQFKNSFKK ILQRALKNVT 120
VSFRETEENA VWIRIAWGTQ YTKPNQYKPT YVVYYSQTPY AFTSSSMLRR NTPLLGQELE 180
ATGKIYLRQE EIILDITEMK KACN 204 |
Gene Ontology | GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell. GO:0005829; C:cytosol; TAS:Reactome. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:Reactome. GO:0000278; P:mitotic cell cycle; TAS:Reactome. |
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