UniProt Accession

 IST1_HUMAN; P53990; A8KAH5; Q3SYM4; Q9BQ81; Q9BWN2 

Genbank Protein ID

 AB097052; D79996; AK057258; AK293022; AK293040; AC009127; BC000116; BC000430; BC004359; BC103745 

Genbank Nucleotide ID

 BAC77405.1; BAA11491.2; BAG51894.1; BAF85711.1; BAF85729.1; AAH00116.1; AAH00430.1; AAH04359.1; AAI03746.1 

Protein Name

 IST1 homolog 

Protein Synonyms/Alias

 hIST1; Putative MAPK-activating protein PM28 

Gene Name

 IST1 

Gene Synonyms/Alias

 KIAA0174 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
151	VNDRLMHKLSVEAPP	ubiquitination	[1]
205	VGFTDDVKKGGPGRG	ubiquitination	[1]
206	GFTDDVKKGGPGRGG	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. 

Sequence Annotation

 REGION 1 168 Interaction with CHMP1A and CHMP1B.
 REGION 64 279 Interaction with VPS37B.
 REGION 190 364 Interaction with VTA1.
 REGION 348 364 Interaction with VPS4A, VTA1, MITD1
 MOTIF 321 332 Type-2 MIT-interacting motif.
 MOTIF 351 361 MIT-interacting motif.  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasmic vesicle; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 364 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0090543; C:Flemming body; IDA:UniProtKB.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0009838; P:abscission; IDA:UniProtKB.
 GO:0000910; P:cytokinesis; IMP:UniProtKB.
 GO:0045862; P:positive regulation of proteolysis; IDA:UniProtKB.
 GO:0008104; P:protein localization; IMP:UniProtKB.
 GO:0019076; P:viral release from host cell; IDA:UniProtKB.
 GO:0046746; P:virus budding from nuclear membrane by viral capsid re-envelopment; IDA:UniProtKB. 

Interpro

 IPR005061; DUF292_euk. 

Pfam

 PF03398; Ist1 

SMART

  

PROSITE

  

PRINTS