CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005458
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rhombotin-2 
Protein Synonyms/Alias
 Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2 
Gene Name
 LMO2 
Gene Synonyms/Alias
 RBTN2; RBTNL1; RHOM2; TTG2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
74VGRRLYYKLGRKLCRubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. 
Sequence Annotation
 DOMAIN 30 89 LIM zinc-binding 1.
 DOMAIN 94 153 LIM zinc-binding 2.  
Keyword
 3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; LIM domain; Metal-binding; Nucleus; Proto-oncogene; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 158 AA 
Protein Sequence
MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW HEDCLSCDLC 60
GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAYEMTMRV KDKVYHLECF 120
KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKINGMI 158 
Gene Ontology
 GO:0005667; C:transcription factor complex; IDA:BHF-UCL.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0048037; F:cofactor binding; IPI:BHF-UCL.
 GO:0070888; F:E-box binding; IDA:BHF-UCL.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0001190; F:RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; IDA:BHF-UCL.
 GO:0001228; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:BHF-UCL.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IDA:UniProtKB.
 GO:0035162; P:embryonic hemopoiesis; IEA:Compara.
 GO:0042789; P:mRNA transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Compara. 
Interpro
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM 
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 
PRINTS