UniProt Accession

 ASB8_HUMAN; Q9H765; A8K1P2; Q547Q2 

Genbank Protein ID

 AF464877; AK024908; AK289957; BC001321 

Genbank Nucleotide ID

 AAQ04830.1; BAB15033.1; BAF82646.1; AAH01321.1 

Protein Name

 Ankyrin repeat and SOCS box protein 8 

Protein Synonyms/Alias

 ASB-8 

Gene Name

 ASB8 

Gene Synonyms/Alias

 PP14212 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
203	VRGLGTEKEDSCFEL	ubiquitination	[1, 2]
239	RDPQLCEKLTVLCSA	ubiquitination	[1]
251	CSAPGTLKTLARYAV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). 

Sequence Annotation

 REPEAT 52 81 ANK 1.
 REPEAT 85 113 ANK 2.
 REPEAT 117 146 ANK 3.
 REPEAT 150 179 ANK 4.
 DOMAIN 235 288 SOCS box.  

Keyword

 ANK repeat; Complete proteome; Cytoplasm; Reference proteome; Repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001496; SOCS_C. 

Pfam

 PF12796; Ank_2
 PF07525; SOCS_box 

SMART

 SM00248; ANK
 SM00969; SOCS_box 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50225; SOCS 

PRINTS