| Tag | Content |
|---|
| CPLM ID | CPLM-006448 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tyrosine-protein phosphatase non-receptor type 7 |
Protein Synonyms/Alias | Hematopoietic protein-tyrosine phosphatase; HEPTP; Protein-tyrosine phosphatase LC-PTP |
Gene Name | PTPN7 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 103 | QLEEEFLKIPSNFVS | ubiquitination | [1] | | 122 | DIPGHASKDRYKTIL | ubiquitination | [1] | | 126 | HASKDRYKTILPNPQ | ubiquitination | [1] | | 226 | QIRIQDMKECPEYTV | ubiquitination | [1] | | 312 | RIGCQQLKARGEVDI | ubiquitination | [1] |
|
Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. |
Sequence Annotation | DOMAIN 97 350 Tyrosine-protein phosphatase.
REGION 38 51 Interaction with MAP kinases.
REGION 291 297 Substrate binding.
ACT_SITE 291 291 Phosphocysteine intermediate.
BINDING 257 257 Substrate.
BINDING 335 335 Substrate.
MOD_RES 44 44 Phosphoserine.
MOD_RES 66 66 Phosphothreonine.
MOD_RES 93 93 Phosphoserine.
MOD_RES 143 143 Phosphoserine.
MOD_RES 291 291 Cysteine sulfenic acid (-SOH) (By |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Hydrolase; Oxidation; Phosphoprotein; Protein phosphatase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 360 AA |
Protein Sequence | MVQAHGGRSR AQPLTLSLGA AMTQPPPEKT PAKKHVRLQE RRGSNVALML DVRSLGAVEP 60
ICSVNTPREV TLHFLRTAGH PLTRWALQRQ PPSPKQLEEE FLKIPSNFVS PEDLDIPGHA 120
SKDRYKTILP NPQSRVCLGR AQSQEDGDYI NANYIRGYDG KEKVYIATQG PMPNTVSDFW 180
EMVWQEEVSL IVMLTQLREG KEKCVHYWPT EEETYGPFQI RIQDMKECPE YTVRQLTIQY 240
QEERRSVKHI LFSAWPDHQT PESAGPLLRL VAEVEESPET AAHPGPIVVH CSAGIGRTGC 300
FIATRIGCQQ LKARGEVDIL GIVCQLRLDR GGMIQTAEQY QFLHHTLALY AGQLPEEPSP 360 |
Gene Ontology | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005829; C:cytosol; IDA:BHF-UCL. GO:0009898; C:internal side of plasma membrane; IDA:UniProtKB. GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |