CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019931
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 
Protein Synonyms/Alias
 DDAH-2; Dimethylarginine dimethylaminohydrolase 2; DDAHII; Dimethylargininase-2 
Gene Name
 Ddah2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
105PEVDGVRKALQDLGLubiquitination[1]
194GSSEAAQKAVRAMAAubiquitination[1]
267VSCSELEKAGAGLSSacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity). 
Sequence Annotation
 ACT_SITE 171 171 Proton donor (By similarity).
 ACT_SITE 276 276 Nucleophile (Potential).  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Mitochondrion; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 285 AA 
Protein Sequence
MGTPGEGLGR CSHALIRGVP ESLASGEGAG AGLPALDLAK AQREHGVLGG KLRQRLGLQL 60
LELPPEESLP LGPLLGDTAV IQGDTALITR PWSPARRPEV DGVRKALQDL GLRIVEMGDE 120
NATLDGTDVL FTGREFFVGL SKWTNHRGAE IVADTFRDFA VSTVPVSGSS HLRGLCGMGG 180
PRTVVAGSSE AAQKAVRAMA ALTDHPYASL TLPDDAASDC LFLRPGLPGA TPFLLHRGGG 240
DLPNSQEALQ KLSDVTLVPV SCSELEKAGA GLSSLCLVLS TRPHC 285 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0016597; F:amino acid binding; IEA:Compara.
 GO:0016403; F:dimethylargininase activity; ISS:UniProtKB.
 GO:0006527; P:arginine catabolic process; ISA:MGI.
 GO:0000052; P:citrulline metabolic process; ISS:UniProtKB. 
Interpro
 IPR003198; Amidino_trans. 
Pfam
 PF02274; Amidinotransf 
SMART
  
PROSITE
  
PRINTS