CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038840
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Gamma-aminobutyric acid receptor subunit alpha-2 
Protein Synonyms/Alias
  
Gene Name
 Gabra2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
390PVLSTISKSATTPEPubiquitination[1]
410NKPAEAKKTFNSVSKubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Complete proteome; Ion channel; Ion transport; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 452 AA 
Protein Sequence
MRTKLSTCNV WFPLLVLLVW NPARLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG 60
LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE RLKFKGPMNI LRLNNLMASK 120
IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD DGTLLYTMRL TVQAECPMHL EDFPMDAHSC 180
PLKFGSYAYT TSEVTYIWTY NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM 240
TAHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA 300
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV NDKPKKEKGS 360
VMIQNNAYAV AVANYAPNLS KDPVLSTISK SATTPEPNKK PENKPAEAKK TFNSVSKIDR 420
MSRIVFPVLF GTFNLVYWAT YLNREPVLGV SP 452 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
 GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
 GO:0006821; P:chloride transport; IEA:InterPro.
 GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. 
Interpro
 IPR006028; GABAA_rcpt.
 IPR001390; GABAAa_rcpt.
 IPR005432; GABBAa2_rcpt.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 
Pfam
 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 
SMART
  
PROSITE
 PS00236; NEUROTR_ION_CHANNEL 
PRINTS
 PR01079; GABAARALPHA.
 PR01615; GABAARALPHA2.
 PR00253; GABAARECEPTR.
 PR00252; NRIONCHANNEL.