UniProt Accession

 TSC10_YEAST; P38342; D6VQR2 

Genbank Protein ID

 X70529; Z36134; BK006936 

Genbank Nucleotide ID

 CAA49930.1; CAA85228.1; DAA07382.2 

Protein Name

 3-ketodihydrosphingosine reductase TSC10 

Protein Synonyms/Alias

 3-dehydrosphinganine reductase; KDS reductase; Temperature-sensitive CSG2 suppressor protein 10 

Gene Name

 TSC10 

Gene Synonyms/Alias

 YBR265W; YBR1734 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
72	DEGQVQHKLAAPLDL	ubiquitination	[1]
223	FTVEQLTKPEITKLI	ubiquitination	[1]
240	PSDAIPCKQACDIIA	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). 

Sequence Annotation

 NP_BIND 11 37 NADP (By similarity).
 ACT_SITE 180 180 Proton acceptor (By similarity).
 ACT_SITE 184 184 By similarity.
 BINDING 167 167 Substrate (By similarity).  

Keyword

 Complete proteome; Endoplasmic reticulum; Lipid metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Sphingolipid metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 320 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
 GO:0047560; F:3-dehydrosphinganine reductase activity; IEA:EC.
 GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IDA:SGD.
 GO:0006666; P:3-keto-sphinganine metabolic process; IDA:SGD.
 GO:0030148; P:sphingolipid biosynthetic process; IDA:SGD. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.