UniProt Accession

 GLPK_HUMAN; P32189; A6NJP5; B2R833; Q6IQ27; Q8IVR5; Q9UMP0; Q9UMP1 

Genbank Protein ID

 L13943; X78211; AJ252550; AJ252551; AJ252552; AJ252553; AJ252554; AJ252555; AJ252556; AJ252557; AJ252558; AJ252559; AJ252560; AJ252561; AJ252562; AJ252563; AJ252564; AJ252565; AJ252566; AJ252567; AJ252568; AJ252569; AJ252570; AJ252550; AJ252551; AJ252552; AJ252553; AJ252554; AJ252555; AJ252556; AJ252557; AJ252559; AJ252560; AJ252561; AJ252562; AJ252563; AJ252564; AJ252565; AJ252566; AJ252567; AJ252568; AJ252569; AJ252570; AJ252550; AJ252551; AJ252552; AJ252553; AJ252554; AJ252555; AJ252556; AJ252557; AJ252559; AJ252560; AJ252561; AJ252562; AJ252563; AJ252564; AJ252565; AJ252566; AJ252567; AJ252568; AJ252570; AK313215; AC005913; AC112496; AC117404; BC037549; BC042421; BC071595; X68285; X69886 

Genbank Nucleotide ID

 AAA52576.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; BAG36030.1; AAH37549.1; AAH42421.1; AAH71595.1; CAA48346.1; CAA49512.1 

Protein Name

 Glycerol kinase 

Protein Synonyms/Alias

 GK; Glycerokinase; ATP:glycerol 3-phosphotransferase 

Gene Name

 GK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MAASKKAVLGPL	ubiquitination	[1, 2]
6	**MAASKKAVLGPLV	ubiquitination	[1, 2, 3]
31	RFLVFNSKTAELLSH	ubiquitination	[1, 2]
86	NIDISNIKAIGVSNQ	ubiquitination	[1, 2]
346	RDNLGIIKTSEEIEK	ubiquitination	[1, 2]
353	KTSEEIEKLAKEVGT	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Key enzyme in the regulation of glycerol uptake and metabolism. 

Sequence Annotation

 NP_BIND 433 437 ATP (By similarity).
 BINDING 20 20 Substrate (By similarity).
 BINDING 24 24 ATP (By similarity).
 BINDING 94 94 Substrate (By similarity).
 BINDING 148 148 Substrate (By similarity).
 BINDING 265 265 Substrate (By similarity).
 BINDING 287 287 ATP (By similarity).
 BINDING 332 332 ATP; via carbonyl oxygen (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Disease mutation; Glycerol metabolism; Kinase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 559 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005741; C:mitochondrial outer membrane; NAS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004370; F:glycerol kinase activity; NAS:UniProtKB.
 GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006071; P:glycerol metabolic process; NAS:UniProtKB.
 GO:0046167; P:glycerol-3-phosphate biosynthetic process; IMP:BHF-UCL.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 

Interpro

 IPR018485; Carb_kinase_FGGY_C.
 IPR018483; Carb_kinase_FGGY_CS.
 IPR018484; Carb_kinase_FGGY_N.
 IPR005999; Glycerol_kin. 

Pfam

 PF02782; FGGY_C
 PF00370; FGGY_N 

SMART

  

PROSITE

 PS00933; FGGY_KINASES_1
 PS00445; FGGY_KINASES_2 

PRINTS