UniProt Accession

 H4_PIG; P62802; P02304; P02305 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Sus scrofa (Pig) 

NCBI Taxa ID

 9823 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKGGKGLGK	acetylation	[1, 2]
9	SGRGKGGKGLGKGGA	acetylation	[1, 2]
13	KGGKGLGKGGAKRHR	acetylation	[1, 2]
17	GLGKGGAKRHRKVLR	acetylation	[1, 2]

Reference

 [1] Patterns of histone acetylation.
 Thorne AW, Kmiciek D, Mitchelson K, Sautiere P, Crane-Robinson C.
 Eur J Biochem. 1990 Nov 13;193(3):701-13. [PMID: 2249688]
 [2] An integrated approach to identifying chemically induced posttranslational modifications using comparative MALDI-MS and targeted HPLC-ESI-MS/MS.
 Person MD, Monks TJ, Lau SS.
 Chem Res Toxicol. 2003 May;16(5):598-608. [PMID: 12755589] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 DNA_BIND 17 21
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 4 4 Asymmetric dimethylarginine; by PRMT1;
 MOD_RES 4 4 Citrulline; alternate (By similarity).
 MOD_RES 4 4 Omega-N-methylarginine; by PRMT1;
 MOD_RES 4 4 Symmetric dimethylarginine; by PRMT5 and
 MOD_RES 6 6 N6-acetyllysine; alternate (By
 MOD_RES 6 6 N6-crotonyl-L-lysine; alternate (By
 MOD_RES 9 9 N6-acetyllysine; alternate (By
 MOD_RES 9 9 N6-crotonyl-L-lysine; alternate (By
 MOD_RES 13 13 N6-acetyllysine; alternate (By
 MOD_RES 13 13 N6-crotonyl-L-lysine; alternate (By
 MOD_RES 17 17 N6-acetyllysine; alternate.
 MOD_RES 17 17 N6-crotonyl-L-lysine; alternate (By
 MOD_RES 21 21 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 21 21 N6,N6-dimethyllysine; alternate.
 MOD_RES 21 21 N6-methyllysine; alternate.
 MOD_RES 32 32 N6-acetyllysine (By similarity).
 MOD_RES 48 48 Phosphoserine; by PAK2 (By similarity).
 MOD_RES 52 52 Phosphotyrosine (By similarity).
 MOD_RES 89 89 Phosphotyrosine (By similarity).
 MOD_RES 92 92 N6-acetyllysine; alternate (By
 CROSSLNK 92 92 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Citrullination; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0045653; P:negative regulation of megakaryocyte differentiation; IEA:Compara.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.