CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045612
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pyruvate kinase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
241GEKGKNIKIISKIENacetylation[1]
241GEKGKNIKIISKIENubiquitination[2]
245KNIKIISKIENHEGVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Glycolysis; Kinase; Magnesium; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 491 AA 
Protein Sequence
MLKPRSKAGT AFIQTQQLHA SMADTFLVHM CGLDIDSVPI TARNLATFVP LPCFRSVEML 60
KMIKSEMNVA QLNSSHGTHE YHAETIKNVH AATEIFGSDP ILNGSGPAEM ELKKGATLKI 120
TLDNAYMEKS ILWLDYKNIC KVVEVASKIY VDDGLISLQV EEKGADYLVS EVENRGSLGS 180
KKGVNLPSTA VDFPAVSEKD IQGLKFGVEQ DVDMVFMSSI RKAADVHEVR KVLGEKGKNI 240
KIISKIENHE GVRRFDEIWE ASDGIMVARG DLSIEIPDKV FLAQKVMIGR CNRLGKPVIC 300
TTQLESVIKK PRPIRAEGSD VVNAVLDGAD CIMLSGETAK GDYLLEAVHI QPLGEVEAAI 360
YHLQLFEELR CLEPITRDPR EAAAVGAVEA SFKCCSGAII VLTKWPGTVR GLLSLQSSDA 420
HQVHLYRGIF PVLCKDAVQD AWAEDVDLRV NLAMNVGKAR GFFKKRDVVI VLTGWHPGCG 480
FTNTIHVVPA P 491 
Gene Ontology
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030955; F:potassium ion binding; IEA:InterPro.
 GO:0004743; F:pyruvate kinase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001697; Pyr_Knase.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
 IPR011037; Pyrv_Knase-like_insert_dom.
 IPR015794; Pyrv_Knase_a/b.
 IPR018209; Pyrv_Knase_AS.
 IPR015793; Pyrv_Knase_brl.
 IPR015795; Pyrv_Knase_C.
 IPR015806; Pyrv_Knase_insert_dom. 
Pfam
 PF00224; PK
 PF02887; PK_C 
SMART
  
PROSITE
 PS00110; PYRUVATE_KINASE 
PRINTS
 PR01050; PYRUVTKNASE.