CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018711
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sprouty-related, EVH1 domain-containing protein 1 
Protein Synonyms/Alias
 Spred-1 
Gene Name
 Spred1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
285DSSVPFSKQDSKKSDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. 
Sequence Annotation
 DOMAIN 6 123 WH1.
 DOMAIN 234 286 KBD.
 DOMAIN 334 442 SPR.
 MOD_RES 239 239 Phosphoserine.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 444 AA 
Protein Sequence
MSEETATSDN DNSYARVRAV VMTRDDSSGG WLPLGGSGLS SVTVFRVPHQ EENGCADFFI 60
RGERLRDKMV VLECMLKKDL IYNKVTPTFH HWKIDDKKFG LTFQSPADAR AFDRGIRRAI 120
EDISLGCPAS KTEAEGGDDD LQTTEEDTSR SLVKDHFFQQ ETVVTSEPYR SSDIRPLPFE 180
DLNARRVYLQ SQVSQIPFSQ QGLDIQSRSM EYVQRQISKE CGSLKSQTRV PLKSIRHVSF 240
QDEDEIVRIN PRDILIRRYA DYRHPDMWKN DLERDDTDSS VPFSKQDSKK SDYLYHCGDE 300
TKLSSLKDSV VFKTQPPSLK FKSKRRKEDG ERSRCVYCQE RFNHEENARG KCQDAPDPVK 360
RCIYQVSCML CAESMLYHCM SDSEGDFSDP CSCDTSDDKF CLRWLALVAL SFIVPCMCCY 420
VPLRMCHRCG EACGCCGGKH KAAG 444 
Gene Ontology
 GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0019902; F:phosphatase binding; ISS:UniProtKB.
 GO:0030291; F:protein serine/threonine kinase inhibitor activity; IDA:BHF-UCL.
 GO:0000188; P:inactivation of MAPK activity; IMP:MGI.
 GO:0007275; P:multicellular organismal development; IEA:InterPro.
 GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IDA:BHF-UCL.
 GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.
 GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IDA:BHF-UCL.
 GO:0090311; P:regulation of protein deacetylation; IDA:BHF-UCL. 
Interpro
 IPR000697; EVH1.
 IPR023337; KBD.
 IPR011993; PH_like_dom.
 IPR007875; Sprouty. 
Pfam
 PF05210; Sprouty
 PF00568; WH1 
SMART
  
PROSITE
 PS51488; KBD
 PS51227; SPR
 PS50229; WH1 
PRINTS