| Tag | Content |
|---|
| CPLM ID | CPLM-021721 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
Protein Synonyms/Alias | NHERF-2; NHE3 kinase A regulatory protein E3KARP; Octs2; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1 |
Gene Name | Slc9a3r2 |
Gene Synonyms/Alias | Nherf2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 90 | TQLLVVDKETDEELC | ubiquitination | [1] | | 169 | GFNLHSDKSRPGQYI | ubiquitination | [1] | | 237 | PETDEHFKRLRVVPT | ubiquitination | [1] | | 282 | SDLPGSEKDNEDGST | ubiquitination | [1] | | 291 | NEDGSTWKRDPFQES | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus (By similarity). |
Sequence Annotation | DOMAIN 11 91 PDZ 1.
DOMAIN 151 231 PDZ 2.
MOD_RES 183 183 Phosphoserine (By similarity).
MOD_RES 254 254 Phosphoserine (By similarity).
MOD_RES 272 272 Phosphoserine. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 337 AA |
Protein Sequence | MAAPESLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL RAGDRLVEVN 60
GVNVEGETHH QVVQRIKAVE GQTQLLVVDK ETDEELCRRQ LTCTEEMAHR GLPPAHNPWE 120
PKPDWACSGS LGSDTGQKDV NGPPRELRPR LCHLRRGPQG YGFNLHSDKS RPGQYIRSVD 180
PGSPASHSGL RAQDRLIEVN GQNVEGLRHA EVVARIKAQE DEARLLVVDP ETDEHFKRLR 240
VVPTEEHVEG PLPSPVTNGT SPAQLNGGSV CSSRSDLPGS EKDNEDGSTW KRDPFQESGL 300
HLSPTAAEAK EKARATRVNK RAPQMDWNRK REIFSNF 337 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IDA:MGI. GO:0005737; C:cytoplasm; IDA:MGI. GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:MGI. GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase cascade; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |