CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038457
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Acacb 
Protein Synonyms/Alias
  
Gene Name
 Acacb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
436EGLQAAEKIGFPLMIubiquitination[1]
456GGGKGIRKAESAEDFubiquitination[1]
653ENPDEGFKPSSGTVQubiquitination[1]
1049RIPAPVEKAVRRVMAubiquitination[1]
1403LYSEEDSKSLREEPIubiquitination[1]
1520YLGAAKVKEGLEVTDubiquitination[1]
1695TKDLLQAKRFQAQSLubiquitination[1]
1720MFRQALFKLWGSPEKubiquitination[1]
1727KLWGSPEKYPKDILTubiquitination[1]
1847VDPEDPHKGFRYLYLubiquitination[1]
1871SQNSVHCKHIEDEGEubiquitination[1]
1889VIVDVIGKDANLGVEubiquitination[1]
2030EIEFTPTKAPYDPRWubiquitination[1]
2155RGFSGGMKDMYEQMLubiquitination[1]
2228PEGTVEIKFRKKDLVubiquitination[1]
2247RIDPVCKKLVGQLGKubiquitination[1]
2397RENINYLKRDSVLKTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Biotin; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2448 AA 
Protein Sequence
MVLLLFLTCL VFSCLTFSWL KIWGKMTDSK PLTNSKVEAN LLSSEESLSA SELSGEQLQE 60
HGDHSCLSYR GPRDASQQRN SLPSSCQRPP RNPLSSNDTW PSPELQTNWT AAPGPEVPDA 120
NGLSFPARPP SQRTVSPSRE DRKQAHIKRQ LMTSFILGSL DDNSSDEDPS AGSFQNSSRK 180
SSRASLGTLS QEAALNTSDP ESHAPTMRPS MSGLHLVKRG REHKKLDLHR DFTVASPAEF 240
VTRFGGNRVI EKVLIANNGI AAVKCMRSIR RWAYEMFRNE RAIRFVVMVT PEDLKANAEY 300
IKMADQYVPV PGGPNNNNYA NVELIIDIAK RIPVQAVWAG WGHASENPKL PELLCKHEIA 360
FLGPPSEAMW ALGDKIASTI VAQTLQIPTL PWSGSGLTVE WTEDSRHQGK CISVPEDVYE 420
QGCVKDVDEG LQAAEKIGFP LMIKASEGGG GKGIRKAESA EDFPMLFRQV QSEIPGSPIF 480
LMKLAQNARH LEVQVLADQY GNAVSLFGRD CSIQRRHQKI IEEAPATIAA PAVFEFMEQC 540
AVLLAKMVGY VSAGTVEYLY SQDGSFHFLE LNPRLQVEHP CTEMIADVNL PAAQLQIAMG 600
VPLHRLKDIR LLYGESPWGV TPIPFETPLS PPIARGHVIA ARITSENPDE GFKPSSGTVQ 660
ELNFRSNKNV WGYFSVAAAG GLHEFADSQF GHCFSWGENR EEAISNMVVA LKELSIRGDF 720
RTTVEYLVNL LETESFQNND IDTGWLDHLI AQRVQAEKPD IMLGVVCGAL NVADAMFRTC 780
MTEFLHSLER GQVLPADSLL NIVDVELIYG GIKYALKVAR QSLTMFVLIM NGCHIEIDAH 840
RLNDGGLLLS YNGSSYTTYM KEEVDSYRIT IGNKTCVFEK ENDPTVLRSP SAGKLMQYTV 900
EDGDHVEAGS SYAEMEVMKM IMTLNVQESG RVKYIKRPGV ILEAGCVVAR LELDDPSKVH 960
AAQPFTGELP AQQTLPILGE KLHQVFHGVL ENLTNVMSGY CLPEPFFSMK LKDWVQKLMM 1020
TLRHPSLPLL ELQEIMTSVA GRIPAPVEKA VRRVMAQYAS NITSVLCQFP SQQIATILDC 1080
HAATLQRKAD REVFFMNTQS IVQLVQRYRS GTRGYMKAVV LDLLRKYLNV EHHFQQAHYD 1140
KCVINLREQF KPDMTQVLDC IFSHSQVAKK NQLVTMLIDE LCGPDPTLSD ELTSILCELT 1200
QLSRSEHCKV ALRARQVLIA SHLPSYELRH NQVESIFLSA IDMYGHQFCP ENLKKLILSE 1260
TTIFDVLPTF FYHENKVVCM ASLEVYVRRG YIAYELNSLQ HRELPDGTCV VEFQFMLPSS 1320
HPNRMAVPIS VSNPDLLRHS TELFMDSGFS PLCQRMGAMV AFRRFEEFTR NFDEVISCFA 1380
NVQTDTLLFS KACTSLYSEE DSKSLREEPI HILNVAIQCA DHMEDEALVP VFRAFVQSKK 1440
HILVDYGLRR ITFLVAQERE FPKFFTFRAR DEFAEDRIYR HLEPALAFQL ELSRMRNFDL 1500
TAVPCANHKM HLYLGAAKVK EGLEVTDHRF FIRAIIRHSD LITKEASFEY LQNEGERLLL 1560
EAMDELEVAF NNTSVRTDCN HIFLNFVPTV IMDPLKIEES VRDMVMRYGS RLWKLRVLQA 1620
EVKINIRQTT SDSAIPIRLF ITNESGYYLD ISLYREVTDS RSGNIMFHSF GNKQGSLHGM 1680
LINTPYVTKD LLQAKRFQAQ SLGTTYVYDF PEMFRQALFK LWGSPEKYPK DILTYTELVL 1740
DSQGQLVEMN RLPGCNEVGM VAFKMRFKTP EYPEGRDAVV IGNDITFQIG SFGIGEDFLY 1800
LRASEMARTE GIPQIYLAAN SGARMGLAEE IKQIFQVAWV DPEDPHKGFR YLYLTPQDYT 1860
QISSQNSVHC KHIEDEGESR YVIVDVIGKD ANLGVENLRG SGMIAGEASL AYEKTVTISM 1920
VTCRALGIGA YLVRLGQRVI QVENSHIILT GAGALNKVLG REVYTSNNQL GGVQIMHTNG 1980
VSHVTVPDDF EGVCTILEWL SFIPKDNRSP VPITTPSDPI DREIEFTPTK APYDPRWMLA 2040
GRPHPTLKGT WQSGFFDHGS FKEIMAPWAQ TVVTGRARLG GIPVGVIAVE TRTVEVAVPA 2100
DPANLDSEAK IIQQAGQVWF PDSAYKTAQV IRDFNKERLP LMIFANWRGF SGGMKDMYEQ 2160
MLKFGAYIVD GLRLYEQPIL IYIPPCAELR GGSWVVLDST INPLCIEMYA DKESRGGVLE 2220
PEGTVEIKFR KKDLVKTIRR IDPVCKKLVG QLGKAQLPDK DRKELEGQLK AREELLLPIY 2280
HQVAVQFADL HDTPGHMLEK GIISDVLEWK TARTFFYWRL RRLLLEAQVK QEILRASPEL 2340
NHEHTQSMLR RWFVETEGAV KAYLWDSNQV VVQWLEQHWS AKDGLRSTIR ENINYLKRDS 2400
VLKTIQSLVQ EHPEVIMDCV AYLSQHLTPA ERIQVAQLLS TTESPASS 2448 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003989; F:acetyl-CoA carboxylase activity; IMP:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004075; F:biotin carboxylase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0006084; P:acetyl-CoA metabolic process; IEA:Compara.
 GO:0006633; P:fatty acid biosynthetic process; IMP:MGI.
 GO:0051289; P:protein homotetramerization; IEA:Compara. 
Interpro
 IPR013537; AcCoA_COase_cen.
 IPR011761; ATP-grasp.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR011764; Biotin_carboxylation_dom.
 IPR005482; Biotin_COase_C.
 IPR000089; Biotin_lipoyl.
 IPR005481; CarbamoylP_synth_lsu_N.
 IPR000022; Carboxyl_trans.
 IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
 IPR011763; COA_CT_C.
 IPR011762; COA_CT_N.
 IPR016185; PreATP-grasp_dom.
 IPR011054; Rudment_hybrid_motif.
 IPR011053; Single_hybrid_motif. 
Pfam
 PF08326; ACC_central
 PF02785; Biotin_carb_C
 PF00364; Biotin_lipoyl
 PF01039; Carboxyl_trans
 PF00289; CPSase_L_chain
 PF02786; CPSase_L_D2 
SMART
 SM00878; Biotin_carb_C 
PROSITE
 PS50975; ATP_GRASP
 PS50979; BC
 PS50968; BIOTINYL_LIPOYL
 PS50989; COA_CT_CTER
 PS50980; COA_CT_NTER
 PS00866; CPSASE_1
 PS00867; CPSASE_2 
PRINTS