UniProt Accession

 SC6B1_YEAST; P52870; D3DLZ4 

Genbank Protein ID

 Z47789; U18839; BK006939 

Genbank Nucleotide ID

 CAA87710.1; AAB64663.1; DAA07748.1 

Protein Name

 Protein transport protein SBH1 

Protein Synonyms/Alias

 Sec61 complex subunit SBH1; Sec61 complex subunit beta 

Gene Name

 SBH1 

Gene Synonyms/Alias

 SEB1; YER087C-B; YER087BC 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
23	RKQGSSQKVAASAPK	ubiquitination	[1]
31	VAASAPKKNTNSNNS	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post- translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP- independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. 

Sequence Annotation

  

Keyword

 Complete proteome; Endoplasmic reticulum; Membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 82 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005784; C:Sec61 translocon complex; IDA:SGD.
 GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IDA:SGD.
 GO:0031204; P:posttranslational protein targeting to membrane, translocation; IDA:SGD.
 GO:0006616; P:SRP-dependent cotranslational protein targeting to membrane, translocation; IMP:SGD. 

Interpro

 IPR005609; Sec61_beta.
 IPR016482; Sec61_beta_euk. 

Pfam

 PF03911; Sec61_beta 

SMART

  

PROSITE

  

PRINTS