CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004760
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Microtubule-associated protein tau 
Protein Synonyms/Alias
 Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau 
Gene Name
 Mapt 
Gene Synonyms/Alias
 Mtapt; Tau 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
565PVPMPDLKNVRSKIGubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. 
Sequence Annotation
 REPEAT 555 585 Tau/MAP 1.
 REPEAT 586 616 Tau/MAP 2.
 REPEAT 617 647 Tau/MAP 3.
 REPEAT 648 679 Tau/MAP 4.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 18 18 Phosphotyrosine; by FYN (By similarity).
 MOD_RES 35 35 Phosphoserine (By similarity).
 MOD_RES 100 100 Phosphothreonine (By similarity).
 MOD_RES 204 204 Phosphoserine; by SGK1 (By similarity).
 MOD_RES 464 464 Phosphothreonine (By similarity).
 MOD_RES 476 476 Phosphothreonine (By similarity).
 MOD_RES 486 486 Phosphothreonine (By similarity).
 MOD_RES 489 489 Phosphoserine (By similarity).
 MOD_RES 492 492 Phosphothreonine.
 MOD_RES 508 508 Phosphotyrosine (By similarity).
 MOD_RES 509 509 Phosphoserine.
 MOD_RES 510 510 Phosphoserine.
 MOD_RES 513 513 Phosphoserine; by CK1, PDPK1 and TTBK1.
 MOD_RES 516 516 Phosphothreonine; by CK1 and PDPK1.
 MOD_RES 523 523 Phosphothreonine; by BRSK1, BRSK2, DYRK2
 MOD_RES 525 525 Phosphoserine (By similarity).
 MOD_RES 528 528 Phosphothreonine (Probable).
 MOD_RES 542 542 Phosphothreonine; by GSK3-beta and PDPK1
 MOD_RES 546 546 Phosphoserine.
 MOD_RES 548 548 Phosphoserine; by PHK (By similarity).
 MOD_RES 573 573 Phosphoserine; by MARK1, BRSK1, BRSK2 and
 MOD_RES 596 596 Phosphoserine; by PHK (By similarity).
 MOD_RES 600 600 Phosphoserine; by PHK (By similarity).
 MOD_RES 604 604 Phosphoserine (By similarity).
 MOD_RES 616 616 Phosphoserine (By similarity).
 MOD_RES 635 635 Phosphoserine (By similarity).
 MOD_RES 663 663 Phosphoserine; by PHK (By similarity).
 MOD_RES 667 667 Phosphoserine (By similarity).
 MOD_RES 707 707 Phosphoserine; by CK1 and PDPK1.
 MOD_RES 711 711 Phosphoserine.
 MOD_RES 714 714 Phosphothreonine (By similarity).
 MOD_RES 715 715 Phosphoserine; by CK1 and PDPK1.
 MOD_RES 720 720 Phosphoserine (By similarity).
 MOD_RES 723 723 Phosphoserine (By similarity).
 MOD_RES 725 725 Phosphothreonine (By similarity).
 MOD_RES 727 727 Phosphoserine (By similarity).
 MOD_RES 733 733 Phosphoserine (By similarity).
 MOD_RES 738 738 Phosphothreonine (By similarity).
 DISULFID 602 633 By similarity.  
Keyword
 Acetylation; Alternative splicing; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disulfide bond; Membrane; Microtubule; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 752 AA 
Protein Sequence
MAEPRQEFDT MEDQAGDYTM LQDQEGDMDH GLKESPPQPP ADDGSEEPGS ETSDAKSTPT 60
AEDVTAPLVE ERAPDKQATA QSHTEIPEGT TAEEAGIGDT PNMEDQAAGH VTQEPQKVEI 120
FSQSLLVEPG RREGQAPDSG ISDWTHQQVP SMSGAPLPPQ GLREATHQPL GTRPEDVERS 180
HPASELLWQE SPQKEAWGKD RLGSEEEVDE DITMDESSQE SPPSQASLAP GTATPQARSV 240
SASGVSGETT SIPGFPAEGS IPLPADFFSK VSAETQASPP EGPGTGPSEE GHEAAPEFTF 300
HVEIKASAPK EQDLEGATVV GAPAEEQKAR GPSVGKGTKE ASLLEPTDKQ PAAGLPGRPV 360
SRVPQLKARV AGVSKDRTGN DEKKAKTSTP SCAKTPSNRP CLSPTRPTPG SSDPLIKPSS 420
PAVCPEPATS PKYVSSVTPR NGSPGTKQMK LKGADGKTGA KIATPRGAAT PGQKGTSNAT 480
RIPAKTTPSP KTPPGSGEPP KSGERSGYSS PGSPGTPGSR SRTPSLPTPP TREPKKVAVV 540
RTPPKSPSAS KSRLQTAPVP MPDLKNVRSK IGSTENLKHQ PGGGKVQIIN KKLDLSNVQS 600
KCGSKDNIKH VPGGGSVHIV YKPVDLSKVT SKCGSLGNIH HKPGGGQVEV KSEKLDFKDR 660
VQSKIGSLDN ITHVPGGGNK KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS 720
NVSSTGSIDM VDSPQLATLA DEVSASLAKQ GL 752 
Gene Ontology
 GO:0044295; C:axonal growth cone; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0045298; C:tubulin complex; ISS:UniProtKB.
 GO:0008017; F:microtubule binding; ISS:UniProtKB.
 GO:0019904; F:protein domain specific binding; IMP:RGD.
 GO:0006915; P:apoptotic process; IDA:RGD.
 GO:0000226; P:microtubule cytoskeleton organization; ISS:UniProtKB.
 GO:0030182; P:neuron differentiation; NAS:RGD.
 GO:0045773; P:positive regulation of axon extension; ISS:UniProtKB.
 GO:0031116; P:positive regulation of microtubule polymerization; ISS:UniProtKB.
 GO:0007584; P:response to nutrient; IDA:RGD.
 GO:0010033; P:response to organic substance; IDA:RGD. 
Interpro
 IPR027324; MAP2/MAP4/Tau.
 IPR001084; Tau/MAP_tubulin-bd_rpt.
 IPR002955; Tau_protein. 
Pfam
 PF00418; Tubulin-binding 
SMART
  
PROSITE
 PS00229; TAU_MAP_1
 PS51491; TAU_MAP_2 
PRINTS
 PR01261; TAUPROTEIN.