CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027958
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FI14922p 
Protein Synonyms/Alias
 Mismatch depedent uracil/thymine DNA glycosylase; Thd1, isoform A; Thd1, isoform B 
Gene Name
 Thd1 
Gene Synonyms/Alias
 Thd1-RA; CG1981; Dmel_CG1981 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
157MSDTKSNKYSEMEKHacetylation[1]
163NKYSEMEKHLNDNSKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1738 AA 
Protein Sequence
MQEESGSTPL LSSSFSYTPT VAPLVLKIAL IQAARSFAAS KYTIKVLLSL NLALSEQAIV 60
QKAVKPICTV MASEVDASSG PEDGTVPTLM SLTPYITNLE HGNNESGKYV SGLPNNRKRQ 120
KLSILEHNTI QNNDVDNTEV EPNMDPKSKM SDTKSNKYSE MEKHLNDNSK IVIEGTISIG 180
NSKRKSPEKL VPYDNDCYMP PEQALVTSVE LVVPAPQTHS SNTPGRQSEE PNLSTLGESS 240
TTPSSTIDNK LQYSTAGLYN STSSTSILAN DKIVGCANDS SNLNLRIPTK LVVTTASGDI 300
LIDDRRASLW TPHHDESGQR QQRTGTASSD TKQEPMNVSS ELSYHHQNRH SELLLQIEKE 360
SSGSFLQASP IPLQDNHNNA ASGQFGQTEE TSNIDSQSHN NFYAQMMQPQ HLLHNQHQQS 420
MHEHSPRHQQ PASYSGYITH YQNPPMFGAH QSEHHQRLNQ QQQPLQHLLD CHGHLEQSTP 480
ISQQNQHHLS QQIHQHQHQQ THQRLPLREN YHDIIMDDFH EEPSHAFKLT LSPSNTKPEN 540
QDDGYETSAG DVLTPNSHSS STHSITPQHQ MQHSNIVLMT QNQKKSDDLQ LTKVTLSGEA 600
HTDPNACSSN SSQGQVLASQ SHLELSEGTR CSSHASVVDP YSFMGEELHM HSPSHRHLDA 660
VTTGPGRYGI LVSNDTPECL SREMYRHSQQ STTVLEQTDS SSCGINFKPM PKKRGRKKKL 720
VAVNADTSQM TTPVDQQKVS AGRADCEDGG GDQAAKPKER KKHDRFNGMS EEEVIKRTIP 780
DHLCDNLDIV IVGINPGLFA AYKGHHYAGP GNHFWKCLYL AGLTQEQMSA DEDHKLIKQG 840
IGFTNMVARA TKGSADLTRK EIKEGSRILL EKLQRFRPKV AVFNGKLIFE VFSGKKEFHF 900
GRQPDRVDGT DTFIWVMPSS SARCAQLPRA ADKVPFYAAL KKFRDFLNGQ IPHIDESECV 960
FTDQRIRLCS AQQQVDIVGK INKTHQPPLG DHPSSLTVVS NCSGPIAGDA ECGIVAEESD 1020
QVQSEKMIPQ MDPTVPSSSN ATDGKSFSYT AENTPLLPVS NHNPSINENN YLSVMGSQQP 1080
LSQQPLEKKK RGRPKKIKGQ DIIDHSVGGK ASIAGQHIPS HDFNNILNLS VMSGGGTIET 1140
PKKKRGRPKK LKPAIDNIMT VKQLQHGNNN LNTTAGLSAS SMHPISMEHI AASPQSSHQM 1200
PPSLYNTPPP SHLLYTASAS PMASPALNCN YTQVHGHGTP PVGQVASVAQ GSSPVIDTQN 1260
DHLAQQKQSH HGNLGAGLDM RDHPHLGETP PPSSPNMCST VDFDPPDEHS GSQVGSRVQN 1320
KAVELDHQHP QIMEKVQYDS PVPNTEANPA HPHENYQQWL SPHPHQSNQP AQKLTHRQQH 1380
PPMHHFHQEQ TENWQRYEEQ NSNPYMVISA HHQHLSPRLG NQTHQNSSPS GHISSDVAHK 1440
SLCGLESLVD QIPAIREQDC SNIPLATVAA AAAAVESRIL SLQHQHQHPL QPHQQNQQNQ 1500
QQQLKQCKQE NSAHRESCRP TSENSNVSNS NFSVSSLAAS ASSARTDNAI YGNGETKGNN 1560
ESSHHNSCDT NIDYPIHNQS AYHHTPHLIG SALGTNVNNS EPNLHTISHP HPPHPHPHSM 1620
YVDQAHHMAH IPSVNVNSMY GPAYGSHPQH TTGEYPGTHG HYSLGGSVQT AVPTSSATLH 1680
VPSPNYPFGH HPYGHTPPQA NYPSYTHPHT HHHHSHPSHH LTVFDHLKPS DISGYGGF 1738 
Gene Ontology
 GO:0003690; F:double-stranded DNA binding; IDA:FlyBase.
 GO:0008263; F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity; IDA:FlyBase.
 GO:0006298; P:mismatch repair; IDA:FlyBase. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR015637; DNA_glycosylase_G/T-mismatch.
 IPR005122; Uracil-DNA_glycosylase-like. 
Pfam
 PF03167; UDG 
SMART
 SM00384; AT_hook
 SM00986; UDG 
PROSITE
  
PRINTS