UniProt Accession

 JUN_MOUSE; P05627 

Genbank Protein ID

 X12761; X12740; J04115; BC002081; BC021888 

Genbank Nucleotide ID

 CAA31252.1; CAA31236.1; AAA37419.1; AAH02081.1; AAH21888.1 

Protein Name

 Transcription factor AP-1 

Protein Synonyms/Alias

 AH119; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; Jun A 

Gene Name

 Jun 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
56	LKPHLRAKNSDLLTS	acetylation	[1]
229	HPRLQALKEEPQTVP	sumoylation	[2, 3, 4]
257	MESQERIKAERKRMR	sumoylation	[3, 4]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] c-Jun and p53 activity is modulated by SUMO-1 modification.
 Muller S, Berger M, Lehembre F, Seeler JS, Haupt Y, Dejean A.
 J Biol Chem. 2000 May 5;275(18):13321-9. [PMID: 10788439]
 [3] Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity.
 Schmidt D, Müller S.
 Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2872-7. [PMID: 11867732]
 [4] Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.
 Bossis G, Malnou CE, Farras R, Andermarcher E, Hipskind R, Rodriguez M, Schmidt D, Muller S, Jariel-Encontre I, Piechaczyk M.
 Mol Cell Biol. 2005 Aug;25(16):6964-79. [PMID: 16055710] 

Functional Description

 Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. 

Sequence Annotation

 DOMAIN 255 318 bZIP.
 REGION 255 282 Basic motif (By similarity).
 REGION 283 311 Leucine-zipper (By similarity).
 MOD_RES 2 2 Phosphothreonine; by PAK2 (By
 MOD_RES 8 8 Phosphothreonine; by PAK2 (By
 MOD_RES 58 58 Phosphoserine (By similarity).
 MOD_RES 63 63 Phosphoserine; by MAPK8 and PLK3 (By
 MOD_RES 73 73 Phosphoserine; by MAPK8 and PLK3
 MOD_RES 89 89 Phosphothreonine; by PAK2 (By
 MOD_RES 93 93 Phosphothreonine; by PAK2 (By
 MOD_RES 242 242 Phosphothreonine; by GSK3-beta (By
 MOD_RES 246 246 Phosphoserine; by DYRK2 and GSK3-beta (By
 MOD_RES 252 252 Phosphoserine; by GSK3-beta (By
 MOD_RES 274 274 N6-acetyllysine (By similarity).
 MOD_RES 289 289 Phosphothreonine; by PAK2 (By  

Keyword

 Acetylation; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005719; C:nuclear euchromatin; IEA:Compara.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0017053; C:transcriptional repressor complex; IPI:MGI.
 GO:0035497; F:cAMP response element binding; IEA:Compara.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0005100; F:Rho GTPase activator activity; IEA:Compara.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0031103; P:axon regeneration; IMP:MGI.
 GO:0071277; P:cellular response to calcium ion; IDA:MGI.
 GO:0051365; P:cellular response to potassium ion starvation; IEA:Compara.
 GO:0007623; P:circadian rhythm; IEA:Compara.
 GO:0035026; P:leading edge cell differentiation; IMP:MGI.
 GO:0007612; P:learning; IEA:Compara.
 GO:0001889; P:liver development; IMP:MGI.
 GO:0051899; P:membrane depolarization; IEA:Compara.
 GO:0001774; P:microglial cell activation; IMP:MGI.
 GO:0030224; P:monocyte differentiation; IMP:MGI.
 GO:0043922; P:negative regulation by host of viral transcription; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
 GO:0043392; P:negative regulation of DNA binding; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
 GO:0031953; P:negative regulation of protein autophosphorylation; IMP:MGI.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0003151; P:outflow tract morphogenesis; IMP:MGI.
 GO:0043923; P:positive regulation by host of viral transcription; IEA:Compara.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IMP:MGI.
 GO:0048146; P:positive regulation of fibroblast proliferation; IDA:MGI.
 GO:0045657; P:positive regulation of monocyte differentiation; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0051726; P:regulation of cell cycle; IMP:MGI.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IDA:MGI.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0009314; P:response to radiation; IEA:Compara.
 GO:0007184; P:SMAD protein import into nucleus; IEA:Compara.
 GO:0060395; P:SMAD protein signal transduction; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Compara. 

Interpro

 IPR004827; bZIP.
 IPR015558; C_Jun.
 IPR008917; Euk_TF_DNA-bd.
 IPR005643; JNK.
 IPR002112; Leuzip_Jun. 

Pfam

 PF00170; bZIP_1
 PF03957; Jun 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS

 PR00043; LEUZIPPRJUN.