CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005219
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Paired box protein Pax-3 
Protein Synonyms/Alias
 HuP2 
Gene Name
 PAX3 
Gene Synonyms/Alias
 HUP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
437SQRLDHMKSLDSLPTacetylation[1]
475YGQYGQSKPWTF***acetylation[1]
Reference
 [1] Role of Pax3 acetylation in the regulation of Hes1 and Neurog2.
 Ichi S, Boshnjaku V, Shen YW, Mania-Farnell B, Ahlgren S, Sapru S, Mansukhani N, McLone DG, Tomita T, Mayanil CS.
 Mol Biol Cell. 2011 Feb 15;22(4):503-12. [PMID: 21169561] 
Functional Description
 Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. 
Sequence Annotation
 DOMAIN 34 161 Paired.
 DNA_BIND 219 278 Homeobox.
 MOD_RES 201 201 Phosphoserine.
 MOD_RES 205 205 Phosphoserine.
 MOD_RES 209 209 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; Deafness; Developmental protein; Disease mutation; DNA-binding; Homeobox; Myogenesis; Neurogenesis; Nucleus; Paired box; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Transcription; Transcription regulation; Waardenburg syndrome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV 60
EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPKQVT TPDVEKKIEE 120
YKRENPGMFS WEIRDKLLKD AVCDRNTVPS VSSISRILRS KFGKGEEEEA DLERKEAEES 180
EKKAKHSIDG ILSERASAPQ SDEGSDIDSE PDLPLKRKQR RSRTTFTAEQ LEELERAFER 240
THYPDIYTRE ELAQRAKLTE ARVQVWFSNR RARWRKQAGA NQLMAFNHLI PGGFPPTAMP 300
TLPTYQLSET SYQPTSIPQA VSDPSSTVHR PQPLPPSTVH QSTIPSNPDS SSAYCLPSTR 360
HGFSSYTDSF VPPSGPSNPM NPTIGNGLSP QVMGLLTNHG GVPHQPQTDY ALSPLTGGLE 420
PTTTVSASCS QRLDHMKSLD SLPTSQSYCP PTYSTTGYSM DPVTGYQYGQ YGQSKPWTF 479 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0006915; P:apoptotic process; TAS:ProtInc.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0048066; P:developmental pigmentation; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0060594; P:mammary gland specification; IEA:Compara.
 GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0001755; P:neural crest cell migration; IEA:Compara.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0048663; P:neuron fate commitment; IEA:Compara.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0007605; P:sensory perception of sound; TAS:ProtInc.
 GO:0021527; P:spinal cord association neuron differentiation; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 
Interpro
 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR001523; Paired_dom.
 IPR022106; Pax7.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00046; Homeobox
 PF00292; PAX
 PF12360; Pax7 
SMART
 SM00389; HOX
 SM00351; PAX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2
 PS00034; PAIRED_1
 PS51057; PAIRED_2 
PRINTS
 PR00027; PAIREDBOX.