| Tag | Content |
|---|
| CPLM ID | CPLM-021792 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium-dependent phosphate transporter 1 |
Protein Synonyms/Alias | Phosphate transporter 1; PiT-1; RPHO-1; Solute carrier family 20 member 1 |
Gene Name | Slc20a1 |
Gene Synonyms/Alias | Pit1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 391 | HKDSGLYKELLHKLH | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor. |
Sequence Annotation | MOD_RES 268 268 Phosphoserine (By similarity).
MOD_RES 269 269 Phosphoserine (By similarity).
MOD_RES 273 273 Phosphoserine (By similarity). |
Keyword | Complete proteome; Membrane; Phosphate transport; Phosphoprotein; Receptor; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 681 AA |
Protein Sequence | MASTLAPITS TLAAVTASAP PKYDNLWMLI LGFIIAFVLA FSVGANDVAN SFGTAVGSGV 60
VTLKQACILA SIFETVGSAL LGAKVSETIR KGLIDVEKYN ATQDLLMAGS VSAMFGSAVW 120
QLVASFLKLP ISGTHCIVGA TIGFSLVAKG QEGIKWSELI KIVMSWFVSP LLSGIMSGIL 180
FFLVRAFILR KADPVPNGLR ALPIFYACTI GINLFSIMYT GAPLLGFDKL PLWGTILISV 240
GCAVFCALIV WFFVCPRMKR KIEREVKSSP SESPLMEKKN NLKDHEETKM APGDVENRNP 300
VSEVVCATGP LRAVVEERTV SFKLGDLEEA PERERLPMDL KEETNIDGTI NGAVQLPNGN 360
LVQFSQTVSN QINSSGHYQY HTVHKDSGLY KELLHKLHLA KVGDCMGDSG DKPLRRNNSY 420
TSYTMAICGM PLDSFRAKEG EQKGDEMETL TWPNADTKKR IRMDSYTSYC NAVSDLHSES 480
EMDMSVKAEM GLGDRKGSSG SLEEWYDQDK PEVSLLFQFL QILTACFGSF AHGGNDVSNA 540
IGPLVALYLV YETRDVTTKE ATPIWLLLYG GVGICMGLWV WGRRVIQTMG KDLTPITPSS 600
GFSIELASAF TVVVASNIGL PISTTHCKVG SVVSVGWLRS KKAVDWRLFR NIFMAWFVTV 660
PISGVISAAI MAVFKHIILP V 681 |
Gene Ontology | GO:0016021; C:integral to membrane; IDA:RGD. GO:0005886; C:plasma membrane; IEA:Compara. GO:0005316; F:high affinity inorganic phosphate:sodium symporter activity; IDA:RGD. GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro. GO:0004871; F:signal transducer activity; IEA:Compara. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |