CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010026
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Serine--tRNA ligase 
Protein Synonyms/Alias
 Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase 
Gene Name
 serS 
Gene Synonyms/Alias
 MPN_005; MP149 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
36EAYVQADKAMRKLLHacetylation[1]
51QIELANQKQTLLAQQacetylation[1]
78ESKELKQKLEQLNIAacetylation[1]
415LKYLDFDKITKPK**acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity). 
Sequence Annotation
 NP_BIND 256 258 ATP (By similarity).
 NP_BIND 343 346 ATP (By similarity).
 REGION 225 227 Serine binding (By similarity).
 BINDING 279 279 Serine (By similarity).
 BINDING 379 379 Serine (By similarity).  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 420 AA 
Protein Sequence
MLDRNKLRNN LDFFKKKLVE RGVSESQFEA YVQADKAMRK LLHQIELANQ KQTLLAQQVA 60
KKKGDPKLLK ESKELKQKLE QLNIAFKEAE TLSQELLLNL PNIADESVPV GRDETANLEL 120
LKEGRKPVFD FTPLPHWELC ERLQLVAFDK ATKLTGARFV AYTDKAAKLL RAIASLMIDL 180
NKNKYQEWNV PVIVNETSLT GTGQLPKFKD DVFKLENTRY YLSPTLEVQL ANLHANEIFT 240
EGELPKYYTA TGVNFRQEAG SAGKQTKGTI RLHQFQKVEL VKFCKPSEAI HELEEMTRDA 300
EQILLELKIP FRRLLLCSGD MGFSAQKTYD LEVWMAGCNE YREVSSCSSC GDFQARRAMI 360
RYKDLTTGKN TYVATLNGTA LAIDRIFAAI LEHYQTKAGE VMIPQALLKY LDFDKITKPK 420 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004828; F:serine-tRNA ligase activity; IEA:HAMAP.
 GO:0016260; P:selenocysteine biosynthetic process; IEA:HAMAP.
 GO:0097056; P:selenocysteinyl-tRNA(Sec) biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006434; P:seryl-tRNA aminoacylation; IEA:HAMAP. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR002317; Ser-tRNA-ligase_type_1.
 IPR015866; Ser-tRNA-synth_1_N.
 IPR010978; tRNA-bd_arm. 
Pfam
 PF02403; Seryl_tRNA_N
 PF00587; tRNA-synt_2b 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR00981; TRNASYNTHSER.