UniProt Accession

 TECR_HUMAN; Q9NZ01; B2RD55; O75350; Q6IBB2; Q9BWK3; Q9Y6P0 

Genbank Protein ID

 AF038958; AF038959; AF222742; AK315412; BT007179; CR456892; BC000174; BC002425; BC005952; BC007801; BC013881 

Genbank Nucleotide ID

 AAC39872.1; AAC39873.1; AAF32373.1; BAG37802.1; AAP35843.1; CAG33173.1; AAH00174.2; AAH02425.1; AAH05952.1; AAH07801.1; AAH13881.1 

Protein Name

 Very-long-chain enoyl-CoA reductase 

Protein Synonyms/Alias

 Synaptic glycoprotein SC2; Trans-2,3-enoyl-CoA reductase; TER 

Gene Name

 TECR 

Gene Synonyms/Alias

 GPSN2; SC2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
2	******MKHYEVEIL	ubiquitination	[1]
12	EVEILDAKTREKLCF	ubiquitination	[1]
73	DLRPAGSKTRKIPYP	ubiquitination	[1]
140	GKHRSYLKEFRDYPP	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids. 

Sequence Annotation

 MOD_RES 22 22 N6-acetyllysine.
 MOD_RES 116 116 N6-acetyllysine (By similarity).
 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; Mental retardation; NADP; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 308 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
 GO:0030497; P:fatty acid elongation; IDA:UniProtKB.
 GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome.
 GO:0042761; P:very long-chain fatty acid biosynthetic process; IDA:UniProtKB. 

Interpro

 IPR001104; 3-oxo-5_a-steroid_4-DH_C. 

Pfam

 PF02544; Steroid_dh 

SMART

  

PROSITE

 PS50244; S5A_REDUCTASE 

PRINTS