UniProt Accession

 CAH1_MOUSE; P13634; Q3TS19; Q9DC84 

Genbank Protein ID

 M32452; L36655; M28197; L36650; L36651; L36652; L36653; L36654; AK003066; AK146372; AK162331; AK167969; AK172076; AC167976; CH466577; BC110681; BC132432; BC132434; BC011223 

Genbank Nucleotide ID

 AAA37354.1; AAA50291.1; AAA50291.1; AAA50291.1; AAA50291.1; AAA50291.1; AAA50291.1; AAA50291.1; BAB22544.1; BAE27121.1; BAE36857.1; BAE39964.1; BAE42813.1; EDL05133.1; AAI10682.1; AAI32433.1; AAI32435.1; AAH11223.1 

Protein Name

 Carbonic anhydrase 1 

Protein Synonyms/Alias

 Carbonate dehydratase I; Carbonic anhydrase I; CA-I 

Gene Name

 Ca1 

Gene Synonyms/Alias

 Car1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
46	ANHDSSLKPLSISYN	acetylation	[1]
46	ANHDSSLKPLSISYN	ubiquitination	[2]
160	PANPSLQKVLDALNS	acetylation	[1]
160	PANPSLQKVLDALNS	ubiquitination	[2]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Reversible hydration of carbon dioxide. 

Sequence Annotation

 REGION 200 201 Substrate binding (By similarity).
 ACT_SITE 65 65 Proton acceptor (By similarity).
 ACT_SITE 129 129 By similarity.
 METAL 95 95 Zinc; catalytic.
 METAL 97 97 Zinc; catalytic.
 METAL 120 120 Zinc; catalytic.
 BINDING 200 200 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Lyase; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004089; F:carbonate dehydratase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro. 

Interpro

 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018338; Carbonic_anhydrase_a-class_CS.
 IPR018442; Carbonic_anhydrase_CA1. 

Pfam

 PF00194; Carb_anhydrase 

SMART

 SM01057; Carb_anhydrase 

PROSITE

 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 

PRINTS