UniProt Accession

 AL1A3_HUMAN; P47895; Q6NT64 

Genbank Protein ID

 U07919; BC069274 

Genbank Nucleotide ID

 AAA79036.1; AAH69274.1 

Protein Name

 Aldehyde dehydrogenase family 1 member A3 

Protein Synonyms/Alias

 Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3 

Gene Name

 ALDH1A3 

Gene Synonyms/Alias

 ALDH6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	NLEVKFTKIFINNEW	ubiquitination	[1]
44	NNEWHESKSGKKFAT	ubiquitination	[2]
150	YFAGWADKIQGKTIP	ubiquitination	[1, 2]
252	SSHPQINKIAFTGST	ubiquitination	[1]
263	TGSTEVGKLVKEAAS	ubiquitination	[1, 2]
266	TEVGKLVKEAASRSN	ubiquitination	[1]
340	RSVEYAKKRPVGDPF	ubiquitination	[1, 2]
350	VGDPFDVKTEQGPQI	ubiquitination	[1, 2]
360	QGPQIDQKQFDKILE	ubiquitination	[1, 2]
373	LELIESGKKEGAKLE	ubiquitination	[1, 2]
394	EDKGLFIKPTVFSEV	ubiquitination	[1, 2]
409	TDNMRIAKEEIFGPV	ubiquitination	[1, 2]
421	GPVQPILKFKSIEEV	ubiquitination	[1, 2]
423	VQPILKFKSIEEVIK	ubiquitination	[1, 2]
430	KSIEEVIKRANSTDY	ubiquitination	[1, 2]
446	LTAAVFTKNLDKALK	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity). 

Sequence Annotation

 NP_BIND 257 262 NAD (By similarity).
 ACT_SITE 280 280 Proton acceptor (By similarity).
 ACT_SITE 314 314 Nucleophile (By similarity).
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Microphthalmia; NAD; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 512 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:Compara.
 GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IDA:UniProtKB.
 GO:0070403; F:NAD+ binding; IEA:Compara.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0070324; F:thyroid hormone binding; IEA:Compara.
 GO:0048048; P:embryonic eye morphogenesis; ISS:UniProtKB.
 GO:0060324; P:face development; IEA:Compara.
 GO:0021768; P:nucleus accumbens development; IEA:Compara.
 GO:0060166; P:olfactory pit development; IEA:Compara.
 GO:0002072; P:optic cup morphogenesis involved in camera-type eye development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0042574; P:retinal metabolic process; IDA:UniProtKB.
 GO:0002138; P:retinoic acid biosynthetic process; IEA:Compara.
 GO:0042573; P:retinoic acid metabolic process; IDA:UniProtKB.
 GO:0042572; P:retinol metabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 

PRINTS